Abstract | BACKGROUND: METHODS: Serum concentrations of TGF-beta1 and 58 SNPs for TGFBR-1 and -2 were examined in 1003 and 1711 men respectively from the Health In Men Study. Validation of SNPs was examined in a second referral cohort of 1043 subjects from New Zealand, of whom 654 had an AAA. RESULTS: Serum TGF-beta1 was not associated with AAA. Only one SNP in TGFBR-2 was weakly associated with AAA; TGFBR2 g.42917C > T, SNP ID rs1078985CC; odds ratio 0.64 (95 per cent confidence interval (c.i.) 0.45 to 0.93); P = 0.020 uncorrected; but this association did not hold after adjusting for multiple testing and was not validated in the New Zealand cohort: odds ratio 0.98 (95 per cent c.i. 0.50 to 1.94); P = 0.960. CONCLUSION: These findings suggest there is no important role of genetic polymorphisms in the main receptors for TGF-beta and circulating TGF-beta1 in AAA in older individuals. (c) 2009 British Journal of Surgery Society Ltd.
|
Authors | J Golledge, P Clancy, G T Jones, M Cooper, L J Palmer, A M van Rij, P E Norman |
Journal | The British journal of surgery
(Br J Surg)
Vol. 96
Issue 6
Pg. 628-32
(Jun 2009)
ISSN: 1365-2168 [Electronic] England |
PMID | 19434696
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Receptors, Transforming Growth Factor beta
- Transforming Growth Factor beta1
- Protein Serine-Threonine Kinases
- Receptor, Transforming Growth Factor-beta Type I
- Receptor, Transforming Growth Factor-beta Type II
- TGFBR1 protein, human
|
Topics |
- Aged
- Aged, 80 and over
- Aortic Aneurysm, Abdominal
(blood, genetics)
- Enzyme-Linked Immunosorbent Assay
- Epidemiologic Methods
- Humans
- Male
- Polymorphism, Genetic
(genetics)
- Protein Serine-Threonine Kinases
(genetics)
- Receptor, Transforming Growth Factor-beta Type I
- Receptor, Transforming Growth Factor-beta Type II
- Receptors, Transforming Growth Factor beta
(genetics)
- Risk Factors
- Transforming Growth Factor beta1
(blood)
|