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Concurrent chemoradiation with carboplatin-5-fluorouracil versus cisplatin in locally advanced oropharyngeal cancers: is more always better?

AbstractPURPOSE:
The optimal chemotherapy regimen remains undefined in the treatment of locally advanced oropharyngeal cancer by concomitant chemoradiation. This article compares two platinum-based chemotherapy regimens.
METHODS AND MATERIALS:
In this retrospective study, we reviewed all consecutive patients treated for Stage III or IVA-B oropharyngeal cancer using either a combination of carboplatin and 5-fluorouracil (5FU) every 3 weeks or high-dose cisplatin every 3 weeks concomitant with definitive radiation therapy.
RESULTS:
A total of 200 patients were treated with carboplatin-5FU and 53 patients with cisplatin. Median potential follow-up was 43 months. The 3-year overall survival rates for carboplatin-5FU and cisplatin respectively were 79.1% and 74.9% (p = 0.628), the 3-year disease-free survival rates were 76.0% and 71.3% (p = 0.799), and the 3-year locoregional control rates were 88.4% and 94.2% (p = 0.244).
CONCLUSIONS:
We could not demonstrate differences between these two regimens, which both proved efficacious. Polychemotherapy and monochemotherapy therefore seem comparable in this retrospective analysis.
AuthorsMaroie Barkati, Bernard Fortin, Denis Soulières, Sébastien Clavel, Phillipe Després, Danielle Charpentier, Jean-Claude Tabet, Louis Guertin, Marie-Jo Olivier, Geneviève Coulombe, David Donath, Phuc Felix Nguyen-Tan
JournalInternational journal of radiation oncology, biology, physics (Int J Radiat Oncol Biol Phys) Vol. 76 Issue 2 Pg. 410-6 (Feb 01 2010) ISSN: 1879-355X [Electronic] United States
PMID19427745 (Publication Type: Comparative Study, Journal Article)
CopyrightCopyright 2010 Elsevier Inc. All rights reserved.
Chemical References
  • Carboplatin
  • Cisplatin
  • Fluorouracil
Topics
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Carboplatin (administration & dosage)
  • Carcinoma, Squamous Cell (drug therapy, mortality, radiotherapy)
  • Cisplatin (administration & dosage)
  • Combined Modality Therapy (methods)
  • Disease-Free Survival
  • Female
  • Fluorouracil (administration & dosage)
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Oropharyngeal Neoplasms (drug therapy, mortality, radiotherapy)
  • Radiotherapy Dosage
  • Retrospective Studies
  • Survival Rate
  • Treatment Outcome

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