Abstract | BACKGROUND:
Influenza A (flu) virus causes significant morbidity and mortality worldwide, and current vaccines require annual updating to protect against the rapidly arising antigenic variations due to antigenic shift and drift. In fact, current subunit or split flu vaccines rely exclusively on antibody responses for protection and do not induce cytotoxic T (Tc) cell responses, which are broadly cross-reactive between virus strains. We have previously reported that gamma-ray inactivated flu virus can induce cross-reactive Tc cell responses. METHODOLOGY/PRINCIPAL FINDING: CONCLUSIONS/SIGNIFICANCE: Intranasal gamma-Flu represents a unique approach for a cross-protective vaccine against both seasonal as well as possible future pandemic influenza A virus infections.
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Authors | Mohammed Alsharifi, Yoichi Furuya, Timothy R Bowden, Mario Lobigs, Aulikki Koskinen, Matthias Regner, Lee Trinidad, David B Boyle, Arno Müllbacher |
Journal | PloS one
(PLoS One)
Vol. 4
Issue 4
Pg. e5336
( 2009)
ISSN: 1932-6203 [Electronic] United States |
PMID | 19401775
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Influenza Vaccines
- RNA, Viral
- Vaccines, Inactivated
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Topics |
- Administration, Intranasal
- Animals
- Cross Reactions
- Female
- Gamma Rays
- Humans
- Influenza A Virus, H1N1 Subtype
(genetics, immunology, pathogenicity)
- Influenza A Virus, H5N1 Subtype
(genetics, immunology, pathogenicity)
- Influenza Vaccines
(administration & dosage)
- Influenza, Human
(immunology, prevention & control, virology)
- Mice
- Mice, Inbred BALB C
- RNA, Viral
(analysis, genetics)
- T-Lymphocytes, Cytotoxic
(immunology)
- Vaccination
(methods)
- Vaccines, Inactivated
(administration & dosage)
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