Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit.

Abstract

Chemoprevention of prostate cancer by second-generation selenium compounds in reference to selenomethionine holds strong promise to deal with the disease at the root. Here we used the transgenic adenocarcinoma mouse prostate (TRAMP) model to establish the efficacy of methylseleninic acid (MSeA) and methylselenocysteine (MSeC) against prostate carcinogenesis and to characterize potential mechanisms. Eight-week-old male TRAMP mice (C57B/6 background) were given a daily oral dose of water, MSeA, or MSeC at 3 mg Se/kg body weight and were euthanized at either 18 or 26 weeks of age. By 18 weeks of age, the genitourinary tract and dorsolateral prostate weights for the MSeA- and MSeC-treated groups were lower than for the control (P < 0.01). At 26 weeks, 4 of 10 control mice had genitourinary weight >2 g, and only 1 of 10 in each of the Se groups did. The efficacy was accompanied by delayed lesion progression, increased apoptosis, and decreased proliferation without appreciable changes of T-antigen expression in the dorsolateral prostate of Se-treated mice and decreased serum insulin-like growth factor I when compared with control mice. In another experiment, giving MSeA to TRAMP mice from 10 or 16 weeks of age increased their survival to 50 weeks of age, and delayed the death due to synaptophysin-positive neuroendocrine carcinomas and synaptophysin-negative prostate lesions and seminal vesicle hypertrophy. Wild-type mice receiving MSeA from 10 weeks did not exhibit decreased body weight or genitourinary weight or increased serum alanine aminotransferase compared with the control mice. Therefore, these selenium compounds may effectively inhibit this model of prostate cancer carcinogenesis.

• Authors: Lei Wang, Melissa J L Bonorden, Guang-xun Li, Hyo-Jeong Lee, Hongbo Hu, Yong Zhang, Joshua D Liao, Margot P Cleary, Junxuan Lü
• Journal: Cancer prevention research (Philadelphia, Pa.) (Cancer Prev Res (Phila)) Vol. 2 Issue 5 Pg. 484-95 (May 2009) ISSN: 1940-6215 [Electronic] United States
• PMID: 19401524 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Antineoplastic Agents
• Organoselenium Compounds
• Selenocysteine
• Insulin-Like Growth Factor I
• Selenomethionine
• Cysteine
• selenomethylselenocysteine

Topics

• Adenocarcinoma (drug therapy, pathology)
• Animals
• Antineoplastic Agents (therapeutic use)
• Apoptosis (drug effects)
• Blotting, Western
• Cell Proliferation (drug effects)
• Cysteine (analogs & derivatives, therapeutic use)
• Enzyme-Linked Immunosorbent Assay
• In Situ Nick-End Labeling
• Insulin-Like Growth Factor I (drug effects)
• Male
• Mice
• Mice, Transgenic
• Organoselenium Compounds (therapeutic use)
• Prostatic Neoplasms (drug therapy, pathology)
• Selenocysteine (analogs & derivatives)
• Selenomethionine (therapeutic use)