Abstract | PURPOSE: To establish the real localization of rifabutin-related corneal deposits in a patient with human immunodeficiency virus ( HIV) infection by in vivo HRT II confocal microscopy with related clinicopathologic implications. METHODS: Observational case report. After Siena University Institutional Review Board approval in May 2008 and specific informed consent, a 54-year-old patient with HIV infection under rifabutin treatment for acquired immunodeficiency syndrome-related Mycobacterium avium complex prevention who developed diffuse corneal deposits was examined at the Department of Ophthalmology of Siena University. He underwent a complete clinical eye examination, biomicroscopy, and digital slit lamp photographs, endothelial specular microscopy, ultrasound pachymetry, and confocal microscopy by HRT II system. RESULTS: Confocal scans revealed the presence of deep stromal and pre descemetic hyperreflective polymorphous deposits. In vivo confocal examination excluded the presence of rifabutin-related deposits at endothelial level. CONCLUSIONS: Confocal microscopy enables establishment of the real localization of rifabutin deposits at deep stromal level, providing a better qualitative analysis of all corneal layers compared to biomicroscopic examination, with clinical and physiopathologic implications.
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Authors | Cosimo Mazzotta, Claudio Traversi, Elisabetta Nuti, Maria Caterina Sparano, Aldo Caporossi |
Journal | European journal of ophthalmology
(Eur J Ophthalmol)
2009 May-Jun
Vol. 19
Issue 3
Pg. 481-3
ISSN: 1120-6721 [Print] United States |
PMID | 19396800
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Anti-HIV Agents
- Rifabutin
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Topics |
- Anti-Bacterial Agents
(adverse effects, therapeutic use)
- Anti-HIV Agents
(therapeutic use)
- Corneal Diseases
(chemically induced, diagnosis)
- Corneal Stroma
(drug effects, pathology)
- HIV Infections
(complications, drug therapy)
- Humans
- Male
- Microscopy, Confocal
- Middle Aged
- Mycobacterium avium-intracellulare Infection
(prevention & control)
- Rifabutin
(adverse effects, therapeutic use)
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