Clinical efficacy of oral administration of 200 mg gatifloxacin once daily for 3 days for the treatment of patients with uncomplicated cystitis.

To assess the clinical efficacy of oral antibiotic administration for the treatment of lower urinary tract infection (UTI), 102 female patients were given gatifloxacin (200 mg once daily for 3 days). Five to nine days after treatment, drug safety and clinical efficacy were assessed by evaluation of urinalysis and symptoms. Further, the patients were asked to report by mail whether they had persistent or recurrent symptoms at 4-6 weeks after treatment. The overall clinical cure rate was 93.1% (95/102). Of 94 patients with susceptible pathogens and 8 with resistant pathogens, 89 (94.7%) and 6 (75.0%), respectively, were judged as clinically cured. Four to 6 weeks after treatment, 57 (55.9%) of the 102 patients reported their micturition status by mail, and 6 (10.5%) of them claimed that they had some symptoms. The outcomes of this study suggest that a therapeutic regimen such as administration of fluoroquinolones once daily for 3 days can be recommended for the treatment of uncomplicated cystitis.
AuthorsShingo Yamamoto, Kikuo Akiyama, Tetsuro Yoshimoto, Mototsugu Kanokogi, Hidenori Yabumoto, Hideari Ihara, Eiji Ishikawa, Masaru Yoshioka, Koji Kokura, Hiroki Shima
JournalJournal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy (J Infect Chemother) Vol. 15 Issue 2 Pg. 104-7 (Apr 2009) ISSN: 1341-321X [Print] Japan
PMID19396520 (Publication Type: Journal Article)
Chemical References
  • Anti-Infective Agents
  • Fluoroquinolones
  • gatifloxacin
  • Adult
  • Anti-Infective Agents (administration & dosage, adverse effects, therapeutic use)
  • Cystitis (drug therapy, microbiology)
  • Drug Administration Schedule
  • Female
  • Fluoroquinolones (administration & dosage, adverse effects, therapeutic use)
  • Gram-Negative Bacteria (drug effects)
  • Gram-Negative Bacterial Infections (drug therapy, microbiology)
  • Gram-Positive Bacteria (drug effects)
  • Gram-Positive Bacterial Infections (drug therapy, microbiology)
  • Humans
  • Microbial Sensitivity Tests
  • Middle Aged
  • Pyuria
  • Treatment Outcome

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