Abstract | PURPOSE: HYPOTHESIS: We hypothesized that dietary chelators would attenuate metal-catalyzed oxidative stress and damage in tissues and protect against pathological changes in ventricular structure and function in type II diabetes. METHODS: Animals (10 weeks old) included lean control (LC, fa/+), untreated Zucker diabetic fatty (ZDF, fa/fa), and ZDF rats treated with either trientine ( triethylenetetramine) or citrate at 20 mg/d in drinking water, starting when rats were frankly diabetic. Cardiac functional assessment was determined using a Millar pressure/volume catheter placed in the left ventricle at 32 weeks of age. RESULTS: End diastolic volume for the ZDF animals increased by 36% indicating LV dilatation (P < .05) and was accompanied by a 30% increase in the end diastolic pressure (P <or= .05). Both trientine and citric acid prevented the increases in EDV and EDP (P < .05). Ejection fraction and myocardial relaxation were also significantly improved with chelator treatment. CONCLUSION:
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Authors | John W Baynes, David B Murray |
Journal | Experimental diabetes research
(Exp Diabetes Res)
Vol. 2009
Pg. 696378
( 2009)
ISSN: 1687-5303 [Electronic] United States |
PMID | 19390595
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chelating Agents
- Citric Acid
- Trientine
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Topics |
- Animals
- Chelating Agents
(pharmacology, therapeutic use)
- Citric Acid
(pharmacology, therapeutic use)
- Diabetes Mellitus, Type 2
(complications, drug therapy, pathology)
- Diabetic Angiopathies
(pathology, prevention & control)
- Drug Evaluation, Preclinical
- Heart Diseases
(complications, pathology, prevention & control)
- Heart Ventricles
(drug effects, pathology)
- Male
- Rats
- Rats, Zucker
- Trientine
(pharmacology, therapeutic use)
- Ventricular Function, Left
(drug effects)
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