Claudins 1, 3, and 4 protein expression in ER negative breast cancer correlates with markers of the basal phenotype.
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| Abstract |
In the present study we investigated the protein expression of claudins 1, 3, and 4 and their relationship to clinical variables and outcome in a cohort of ER-ve and ER+ve human invasive breast cancers. Immunohistochemical analysis was performed on tissue microarrays representing a total of 412 tumors and interpretable data was derived from 314, 299, and 306 tumors for claudins 1, 3, and 4, respectively. In the ER+ve subset, 5%, 89%, and 52%, and in the ER-ve subset, 39%, 79%, and 79% of tumors stained positively for claudins 1, 3, and 4, respectively (p < 0.0001, p = 0.026, p < 0.0001). Thus, in the two subsets, a significantly higher number of tumors were positive for claudins 3 and 4, compared to claudin 1. In addition, protein expressions of claudins 1 and 4 were significantly higher in those tumors that displayed characteristics of the basal-like subtype of breast cancers (ER-ve, Her-2-ve, EGFR+ve, CK5/6+ve). This study shows a unique pattern of expression for the different claudins in ER-ve and ER+ve tumors. Our data also suggests that increased expression of claudins 1 and 4 was associated with the basal-like subtype of breast cancers, a subtype generally linked to poor outcome.
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| Authors | Anne A Blanchard, George P Skliris, Peter H Watson, Leigh C Murphy, Carla Penner, Ladislav Tomes, Tamara L Young, Etienne Leygue, Yvonne Myal |
| Journal | Virchows Archiv : an international journal of pathology (Virchows Arch) Vol. 454 Issue 6 Pg. 647-56 (Jun 2009) ISSN: 1432-2307 [Electronic] Germany |
| PMID | 19387682 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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