Abstract | SETTING: OBJECTIVE: To evaluate predictors of treatment outcomes and survival among non-human immunodeficiency virus (HIV) infected patients with extensively drug-resistant TB ( XDR-TB). DESIGN: Patients who were diagnosed with XDR-TB at the National Masan Tuberculosis Hospital from January 2001 to December 2005 were included in this study. We conducted a retrospective review of their medical records and mortality data. RESULTS: A total of 176 non-HIV-infected patients with XDR-TB were included. TB-related mortality was 48% (84/176), and the median survival time from the diagnosis date of XDR-TB was 51 months (range 0-127, 95%CI 32.53-69.47). Cure and treatment completion were classified as favourable outcome and treatment failure, death during treatment and default as poor outcome. Previous TB treatment with second-line drugs (aOR 2.76, 95%CI 1.02-7.44) and cavitary disease (aOR 3.01, 95%CI 1.12-8.08) were independent risk factors for poor outcome. Use of linezolid (aOR 0.10, 95%CI 0.01-0.69) and surgical resection (aOR 0.18, 95%CI 0.04-0.78) were associated with favourable outcome. CONCLUSION: There was high mortality in non-HIV-infected patients with XDR-TB at a TB referral hospital in South Korea. Adjunctive surgical treatment and linezolid improved the outcome for selected patients with XDR-TB.
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Authors | D S Jeon, D H Kim, H S Kang, S H Hwang, J H Min, J H Kim, N M Sung, M W Carroll, S K Park |
Journal | The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
(Int J Tuberc Lung Dis)
Vol. 13
Issue 5
Pg. 594-600
(May 2009)
ISSN: 1027-3719 [Print] France |
PMID | 19383192
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adult
- Antitubercular Agents
(therapeutic use)
- Extensively Drug-Resistant Tuberculosis
(mortality, therapy)
- Female
- Follow-Up Studies
- HIV Infections
- Hospitals, Special
(statistics & numerical data)
- Humans
- Korea
(epidemiology)
- Male
- Pneumonectomy
(methods)
- Retrospective Studies
- Survival Rate
(trends)
- Treatment Outcome
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