Abstract |
Kaposiform hemangioendothelioma is a rare vascular tumor of childhood that is locally aggressive but has little metastatic potential and by itself is not known to be lethal. It most commonly presents as a superficial or deep soft tissue mass with associated cutaneous lesions. Kasabach-Merritt phenomenon, a condition characterized by profound thrombocytopenia and life-threatening hemorrhage, often is associated with kaposiform hemangioendothelioma. Six cases of kaposiform hemangioendothelioma have been reported in bone, two of which were located in extracraniofacial bones. We report a diagnostically challenging case of a 6-year-old girl with kaposiform hemangioendothelioma of the thoracolumbar spine without Kasabach-Merritt phenomenon or cutaneous lesions.
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Authors | Jennifer W Lisle, Heather A Bradeen, Alexandra N Kalof |
Journal | Clinical orthopaedics and related research
(Clin Orthop Relat Res)
Vol. 467
Issue 9
Pg. 2464-71
(Sep 2009)
ISSN: 1528-1132 [Electronic] United States |
PMID | 19381744
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Angiogenesis Inhibitors
- Anti-Inflammatory Agents, Non-Steroidal
- Biomarkers, Tumor
- Platelet Endothelial Cell Adhesion Molecule-1
- Pyrazoles
- Sulfonamides
- Thalidomide
- Celecoxib
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Topics |
- Angiogenesis Inhibitors
(therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Biomarkers, Tumor
(analysis)
- Celecoxib
- Child
- Drug Therapy, Combination
- Female
- Hemangioendothelioma
(complications, drug therapy, pathology)
- Humans
- Lumbar Vertebrae
(diagnostic imaging, pathology)
- Pain
(etiology)
- Platelet Endothelial Cell Adhesion Molecule-1
(analysis)
- Pyrazoles
(therapeutic use)
- Radiography
- Sarcoma, Kaposi
(complications, drug therapy, pathology)
- Spinal Neoplasms
(complications, drug therapy, pathology)
- Sulfonamides
(therapeutic use)
- Syndrome
- Thalidomide
(therapeutic use)
- Thoracic Vertebrae
(diagnostic imaging, pathology)
- Treatment Outcome
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