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Kaposiform hemangioendothelioma in multiple spinal levels without skin changes.

Abstract
Kaposiform hemangioendothelioma is a rare vascular tumor of childhood that is locally aggressive but has little metastatic potential and by itself is not known to be lethal. It most commonly presents as a superficial or deep soft tissue mass with associated cutaneous lesions. Kasabach-Merritt phenomenon, a condition characterized by profound thrombocytopenia and life-threatening hemorrhage, often is associated with kaposiform hemangioendothelioma. Six cases of kaposiform hemangioendothelioma have been reported in bone, two of which were located in extracraniofacial bones. We report a diagnostically challenging case of a 6-year-old girl with kaposiform hemangioendothelioma of the thoracolumbar spine without Kasabach-Merritt phenomenon or cutaneous lesions.
AuthorsJennifer W Lisle, Heather A Bradeen, Alexandra N Kalof
JournalClinical orthopaedics and related research (Clin Orthop Relat Res) Vol. 467 Issue 9 Pg. 2464-71 (Sep 2009) ISSN: 1528-1132 [Electronic] United States
PMID19381744 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Angiogenesis Inhibitors
  • Anti-Inflammatory Agents, Non-Steroidal
  • Biomarkers, Tumor
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Pyrazoles
  • Sulfonamides
  • Thalidomide
  • Celecoxib
Topics
  • Angiogenesis Inhibitors (therapeutic use)
  • Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
  • Biomarkers, Tumor (analysis)
  • Celecoxib
  • Child
  • Drug Therapy, Combination
  • Female
  • Hemangioendothelioma (complications, drug therapy, pathology)
  • Humans
  • Lumbar Vertebrae (diagnostic imaging, pathology)
  • Pain (etiology)
  • Platelet Endothelial Cell Adhesion Molecule-1 (analysis)
  • Pyrazoles (therapeutic use)
  • Radiography
  • Sarcoma, Kaposi (complications, drug therapy, pathology)
  • Spinal Neoplasms (complications, drug therapy, pathology)
  • Sulfonamides (therapeutic use)
  • Syndrome
  • Thalidomide (therapeutic use)
  • Thoracic Vertebrae (diagnostic imaging, pathology)
  • Treatment Outcome

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