[Prognostic value of big endothelin-1 prognostic value in patients with heart failure and moderately symptomatic functional class].

Abstract

BACKGROUND AND OBJECTIVE:

Several studies have analyzed big endothelin-1 as a marker of mortality in patients with severe heart failure (HF). However, it has not proven prognostic value in patients with moderately symptomatic functional class. Our objective was to evaluate, in a 24 months follow-up, the prognostic power of big endothelin-1 in patients with HF and moderately deteriorated functional class.

MATERIAL AND METHOD:

Big endothelin-1 levels were measured in a cohort of 90 outpatients (age 64 (13), 70% males) diagnosed with HF. Patients were functionally classified (NYHA).

RESULTS:

For the whole population, big endothelin-1 was 0.86 (0.61-1.20)fmol/ml. We evaluated its predictive value in detecting cardiovascular mortality, obtaining an AUC of 0.68 (0.08) (P=.02), and a cut-off value of 0.98 fmol/ml (sensitivity 69%, specificity 75%). When a logistic regression analysis was performed, big endothelin-1 was also an independent predictor of mortality (OR=5.851, P=.009).

CONCLUSIONS:

Big endothelin-1 predicts cardiovascular mortality in patients diagnosed of HF and moderately symptomatic functional class.

• Authors: Esther Roselló-Lletí, Miguel Rivera, Vicente Miró, Raquel Cortés, Luís Martínez-Dolz, Manuel Portolés
• Journal: Medicina clinica (Med Clin (Barc)) Vol. 133 Issue 5 Pg. 173-6 (Jul 04 2009) ISSN: 0025-7753 [Print] Spain
• Vernacular Title: Valor pronóstico de big endotelina-1 en pacientes con insuficiencia cardíaca y clase funcional moderadamente sintomática.
• PMID: 19376546 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Endothelin-1

Topics

• Endothelin-1 (blood)
• Female
• Follow-Up Studies
• Heart Failure (blood, classification, mortality, physiopathology)
• Humans
• Male
• Middle Aged
• Predictive Value of Tests
• Prognosis
• Prospective Studies