Boron biodistribution study in colorectal liver metastases patients in Argentina.

Abstract

Ex-situ BNCT for multifocal unresectable liver metastases employing whole or partial autograft techniques requires knowledge of boron concentrations in healthy liver and metastases following perfusion and immersion in Wisconsin solution (W), the procedure employed for organ preservation during ex-situ irradiation. Measurements of boron concentration in blood, liver and metastases following an intravenous infusion of BPA-F in five colorectal liver metastases patients scheduled for surgery were performed. Tissue samples were evaluated for boron content pre and post perfusion and immersion in W. Complementary histological studies were performed. The data showed a dose-dependent BPA uptake in liver, a boron concentration ratio liver/blood close to 1 and a wide spread in the metastases/liver concentration ratios in the range 0.8-3.6, partially attributable to histological variations between samples. Based on the boron concentrations and dose considerations (liver < or =15 Gy-Eq and tumor> or =40 Gy-Eq) at the RA-3 thermal neutron facility (mean flux of about (6+/-1) x 10(9) n cm(-2)s(-1)), ex-situ treatment of liver metastases at RA-3 would be feasible.

• Authors: J Cardoso, S Nievas, M Pereira, A Schwint, V Trivillin, E Pozzi, E Heber, A Monti Hughes, P Sanchez, E Bumaschny, M Itoiz, S Liberman
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 67 Issue 7-8 Suppl Pg. S76-9 (Jul 2009) ISSN: 1872-9800 [Electronic] England
• PMID: 19375931 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Boron Compounds
• Isotopes
• Radiation-Sensitizing Agents
• Phenylalanine
• Boron
• 4-boronophenylalanine

Topics

• Adenocarcinoma (metabolism, radiotherapy, secondary, surgery)
• Aged
• Argentina
• Boron (blood, pharmacokinetics)
• Boron Compounds (administration & dosage, pharmacokinetics, therapeutic use)
• Boron Neutron Capture Therapy
• Colorectal Neoplasms (metabolism)
• Female
• Humans
• In Vitro Techniques
• Infusions, Intravenous
• Isotopes (blood, pharmacokinetics)
• Liver (metabolism)
• Liver Neoplasms (metabolism, radiotherapy, secondary, surgery)
• Liver Transplantation
• Male
• Middle Aged
• Phenylalanine (administration & dosage, analogs & derivatives, pharmacokinetics, therapeutic use)
• Radiation-Sensitizing Agents (administration & dosage, pharmacokinetics, therapeutic use)
• Tissue Distribution
• Transplantation, Autologous