Sequential evaluation of serum monocyte chemotactic protein 1 among asymptomatic state and acute exacerbation and remission of asthma in children.

Abstract

BACKGROUND:

Monocyte chemotactic protein 1 (MCP-1) plays an important role in various immune and allergic disorders since it is a potent chemo-attractant for inflammatory cells, such as eosinophils, memory T cells, and monocytes.

OBJECTIVE:

To investigate serum MCP-1 during asymptomatic state and acute attacks of bronchial asthma.

METHODS:

In this longitudinal cohort design study, sequential serum levels of MCP-1 were measured by a sandwich enzyme-linked immunosorbent assay (ELISA). Twenty-four asthma patients' MCP-1 levels were examined at 5 time points: during the asymptomatic phase, in an acute wheezing episode, and at 1 week, 1 month, and 2 months after acute asthma attack. Fifteen children without asthma were enrolled as control.

RESULTS:

During the asymptomatic phase of asthma, serum MCP-1 levels were significantly higher than that of normal controls (329.57 +/- 99.20 pg/ml vs. 213.63 +/- 77.29 pg/ml, p = 0.001). In comparison with the asymptomatic phase, the serum MCP-1 levels during the acute asthma attack were significantly higher (682.88 +/- 88.45 pg/ml vs. 329.57 +/- 99.20 pg/ml, p < 0.001). After treatment of acute asthma exacerbation, all of the serum MCP-1 levels declined within 1 week, but were still higher than control 2 months later.

CONCLUSION:

In asthma patients, the consistently elevated serum levels of MCP-1 suggest its role in the pathogenesis of bronchial asthma - not only in the chronic inflammatory processes, but also in acute asthma attack exacerbation. These findings suggest a possible role for MCP-1 in the pathogenesis of asthma and a potential role for its use in anti-asthma treatment in the future.

• Authors: Chin-Kan Chan, Ming-Ling Kuo, Kuo-Wei Yeh, Liang-Shiou Ou, Li-Chen Chen, Tsung-Chieh Yao, Jing-Long Huang
• Journal: The Journal of asthma : official journal of the Association for the Care of Asthma (J Asthma) Vol. 46 Issue 3 Pg. 225-8 (Apr 2009) ISSN: 1532-4303 [Electronic] England
• PMID: 19373627 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Androstadienes
• Bronchodilator Agents
• Chemokine CCL2
• Fluticasone
• Terbutaline

Topics

• Acute Disease
• Adolescent
• Androstadienes (therapeutic use)
• Asthma (blood, drug therapy)
• Bronchodilator Agents (therapeutic use)
• Chemokine CCL2 (biosynthesis, blood)
• Child
• China
• Enzyme-Linked Immunosorbent Assay
• Female
• Fluticasone
• Humans
• Longitudinal Studies
• Male
• Respiratory Function Tests
• Terbutaline (therapeutic use)