Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Both HDL and mimetic peptides are able to scavenge and sequester oxidized lipids and hence protect endothelial cells and arteries from the pro-inflammatory action of oxidized LDL. Active mimetic peptides have an amphipathic alpha-helical secondary structure, whose hydrophobic face is particularly important for its bioactivity. The most frequently employed peptide is 4F. The comparative bioactivity of variants of 4F, particularly tandem helical peptides, has been explored. The recent observation of the very high affinity of bioactive peptides for oxidized fatty acids and phospholipids provides a likely mechanism for the action of these peptides in inhibiting early atherosclerosis formation. It is not clear that these peptides alone are effective in reversing established atherosclerosis, although they may achieve this outcome in synergy with statin therapy. SUMMARY:
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Authors | Godfrey S Getz, Geoffrey D Wool, Catherine A Reardon |
Journal | Current opinion in lipidology
(Curr Opin Lipidol)
Vol. 20
Issue 3
Pg. 171-5
(Jun 2009)
ISSN: 1473-6535 [Electronic] England |
PMID | 19373084
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Apolipoprotein A-I
- Peptides
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Topics |
- Animals
- Apolipoprotein A-I
(chemistry)
- Atherosclerosis
(drug therapy, physiopathology, prevention & control)
- Biomimetic Materials
(chemistry, pharmacology, therapeutic use)
- Blood Vessels
(drug effects)
- Humans
- Peptides
(chemistry, pharmacology, therapeutic use)
- Protein Structure, Secondary
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