Abstract | PURPOSE OF REVIEW:
HIV infection is characterized by depletion of CD4 T cells and altered immune function, leading to severe immune deficiency. Mechanisms leading to this T-cell depletion are not completely understood. Potent antiretroviral therapy restores T-cell counts and improves prognosis. Apart from antiviral therapy for the infection, immunotherapies such as interleukin-7 that influence T-cell homeostatic mechanisms are undergoing clinical evaluation. Because of its pleiotropic effects on developing and mature T cells, interleukin-7 may help to restore immune function during HIV infection. RECENT FINDINGS: SUMMARY: Numerous recent findings highlight the importance of interleukin-7 pathway impairment in the pathogenesis of HIV infection. Notably, interleukin-7 levels increased with advancing CD4 T-cell lymphopenia, whereas interleukin-7 receptor expression is downregulated mainly on CD8 T cells. Therapeutic trials conducted in monkeys and in humans (phase I) have provided evidence on the role of interleukin-7 in thymopoiesis and in restoration of T-cell functions. Interleukin-7 appeared to be well tolerated and to have no deleterious effects on viral load. These results should be confirmed in larger phase I/II studies.
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Authors | Jean Daniel Lelièvre, Yves Lévy |
Journal | Current opinion in HIV and AIDS
(Curr Opin HIV AIDS)
Vol. 2
Issue 3
Pg. 228-33
(May 2007)
ISSN: 1746-6318 [Electronic] United States |
PMID | 19372891
(Publication Type: Journal Article)
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