Abstract | INTRODUCTION: The aim of this retrospective analysis was to analyze the results of conventional radical radiotherapy in the treatment of oropharyngeal cancer and to identify pre-treatment and treatment-related prognostic factors for outcome. MATERIAL AND METHODS: RESULTS: The median age was 56 years. History of tobacco abuse was present in 80.5%. Eighty six percent had stage III or IV disease. Radical radiotherapy alone was the treatment modality for 71.2% and concomitant or neoadjuvant chemotherapy was used in 28.8%. The 3-year local control (LC), loco-regional control (LRC), disease-free survival (DFS) and overall survival (OS) was 49%, 40.6%, 38.9% and 36.1% respectively. The 3-year DFS rates were 80.3% for stage I, 65.8% for stage II, 46.1% for stage III and 25.2% for stage IV disease. Multivariate analysis was performed for prognostic factors. Prior history of tobacco abuse was an independent prognostic factor for both DFS and LRC. Karnofsky Performance Score (KPS) < 80, higher nodal stage, lower total radiotherapy dose (<66 Gy) in those receiving > 60 Gy, and overall treatment time > 50 days were other independent prognostic factors for inferior DFS and LRC. KPS < 80, higher T stage, higher nodal stage, RT dose < 66 Gy and longer overall treatment time (>50 days) were independent prognostic factors for poorer local control. CONCLUSIONS:
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Authors | Jai Prakash Agarwal, Indranil Mallick, Ritu Bhutani, Sarbani Ghosh-Laskar, Tejpal Gupta, Ashwini Budrukkar, Vedang Murthy, Manju Sengar, Ketayun A Dinshaw |
Journal | Acta oncologica (Stockholm, Sweden)
(Acta Oncol)
Vol. 48
Issue 7
Pg. 1026-33
( 2009)
ISSN: 1651-226X [Electronic] England |
PMID | 19363712
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Disease-Free Survival
- Female
- Humans
- Karnofsky Performance Status
- Male
- Middle Aged
- Multivariate Analysis
- Neoadjuvant Therapy
- Neoplasm Staging
- Neoplasms, Squamous Cell
(mortality, pathology, radiotherapy)
- Oropharyngeal Neoplasms
(mortality, pathology, radiotherapy)
- Prognosis
- Radiotherapy Dosage
- Radiotherapy, Conformal
- Retrospective Studies
- Smoking
(adverse effects)
- Time Factors
- Treatment Outcome
- Young Adult
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