Abstract | OBJECTIVES: BACKGROUND:
Stress cardiomyopathy is a syndrome of transient cardiac dysfunction precipitated by intense emotional or physical stress. Excessive sympathetic stimulation is believed to be central to the pathogenesis of this disorder, but a causal link has not been convincingly demonstrated. METHODS: RESULTS: The median age was 44 years (interquartile range [IQR]: 30 to 48 years), and 7 (78%) were woman. Troponin-I was mildly elevated (median 4.07 ng/ml, IQR: 0.47 to 5.63 ng/ml), but none of the patients undergoing angiography had obstructive coronary disease. All patients developed corrected QT interval (QTc interval) prolongation (median QTc interval 504 ms, IQR: 477 to 568 ms) within 24 h of receiving drug. All 3 previously described variants of left ventricular "ballooning" (apical, midventricular, and basal) were observed. The median ejection fraction on admission was 35% (IQR: 35% to 40%). During follow-up (median 7 days, IQR: 4 to 13 days) there was recovery of left ventricular systolic function in all patients (median ejection fraction 55%, IQR: 40% to 60%, p < 0.001 vs. admission). CONCLUSIONS: Exposure to catecholamines and beta-receptor agonists used routinely during procedures and diagnostic tests can precipitate all the features of stress cardiomyopathy, including cardiac isoenzyme elevation, QTc interval prolongation, and rapidly reversible cardiac dysfunction. These observations strongly implicate excessive sympathetic stimulation as central to the pathogenesis of this unique syndrome.
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Authors | Jacob Abraham, James O Mudd, Navin K Kapur, Navin Kapur, Kelly Klein, Hunter C Champion, Ilan S Wittstein |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 53
Issue 15
Pg. 1320-5
(Apr 14 2009)
ISSN: 1558-3597 [Electronic] United States |
PMID | 19358948
(Publication Type: Journal Article)
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Chemical References |
- Adrenergic beta-Agonists
- Cardiovascular Agents
- Catecholamines
- Dobutamine
- Epinephrine
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Topics |
- Adrenergic beta-Agonists
(administration & dosage, adverse effects)
- Adult
- Cardiomyopathies
(chemically induced)
- Cardiovascular Agents
(administration & dosage, adverse effects)
- Catecholamines
(administration & dosage, adverse effects)
- Dobutamine
(administration & dosage, adverse effects)
- Epinephrine
(administration & dosage, adverse effects)
- Female
- Humans
- Infusions, Intravenous
- Male
- Middle Aged
- Ventricular Dysfunction, Left
(chemically induced)
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