Comparative efficacy of levo-praziquantel and praziquantel in treatment of schistosomiasis japonica at a single dose.

Abstract

The result of a randomized double blind comparison of therapeutic efficacy of single doses of levo-praziquantel (L-PZQ) and praziquantel (PZQ) in the treatment of 139 matched pairs of proved cases of schistosomiasis japonica was reported, 268 were chronic early cases and 10 were late cases. The dosage of L-PQZ was 20 mg/kg, and that of PZQ was 40 mg/kg. Four and 6 months after treatment the stool-ova negative conversion rates were 94.8% and 96.3% for the L-PZQ group, and 97.1% and 94.0% for the PZQ group respectively (P greater than 0.05).

• Authors: M H Wu, C C Wei, Z Y Xu, H C Yuan, W N Lian, Q J Yang, M Chen, C Z Wang, Z J Zhang, Z D Liu
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 104 Issue 9 Pg. 732-5 (Sep 1991) ISSN: 0366-6999 [Print] China
• PMID: 1935353 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Praziquantel

Topics

• Adolescent
• Adult
• Child
• Child, Preschool
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Praziquantel (administration & dosage, therapeutic use)
• Schistosomiasis japonica (drug therapy)
• Stereoisomerism