Abstract | CONTEXT: AIMS: MATERIAL AND METHODS: STATISTICAL ANALYSIS: Chi square test and test for validity were used for analysis of differences in expression. RESULTS: Expression of ICAM and VCAM was significantly upregulated on blood vessels and muscle fibres in IMs as compared to controls, in which expression was weak or absent. LFA and VLA-4 were expressed in inflammatory cells in all inflammatory diseases in almost equal numbers. CONCLUSIONS: IMs comprise 6% of all muscle diseases and IBM is not a common IM in India as reported in the Western literature. Our findings support the hypothesis of autoimmune origin of IMs. The difference between expression of these molecules in IMs and controls also has diagnostic implications and these markers should be included along with MHC-1 antigen and membrane attack complex (MAC) in the existing diagnostic armamentarium.
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Authors | Ayushi Jain, Mehar C Sharma, Chitra Sarkar, Rohit Bhatia, Sumit Singh, Rohini Handa |
Journal | Folia neuropathologica
(Folia Neuropathol)
Vol. 47
Issue 1
Pg. 33-42
( 2009)
ISSN: 1641-4640 [Print] Poland |
PMID | 19353432
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Integrin alpha4beta1
- Lymphocyte Function-Associated Antigen-1
- Vascular Cell Adhesion Molecule-1
- Intercellular Adhesion Molecule-1
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Topics |
- Biomarkers
(analysis)
- Endothelium, Vascular
(metabolism)
- Humans
- Immunohistochemistry
- Integrin alpha4beta1
(biosynthesis)
- Intercellular Adhesion Molecule-1
(biosynthesis)
- Lymphocyte Function-Associated Antigen-1
(biosynthesis)
- Myositis
(diagnosis, metabolism)
- Retrospective Studies
- Sensitivity and Specificity
- Vascular Cell Adhesion Molecule-1
(biosynthesis)
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