Clinical usefulness of a supplementary cyclosporin administration with a topical application of maxacalcitol ointment for patients with moderate psoriasis vulgaris.

Abstract

In this study, we aimed at confirming the clinical usefulness of a supplementary additional cyclosporin microemulsion preconcentrate (CyA MEPC) administration in 15 patients with psoriasis vulgaris whose disease activity had been unchanged or exacerbated with topical maxacalcitol treatment. Each patient took a supplementary CyA MEPC administration, 2.5 mg/kg per day in addition to maxacalcitol ointment therapy. When the Psoriasis Area and Severity Index (PASI) score revealed over a 75% decrease against the initial value, the administration of CyA MEPC was tapered off, and a topical application of maxacalcitol ointment was continued for the maintenance phase. All patients could obtain improvement within 12 weeks. In 12 patients whose PASI score reduced over 75%, CyA MEPC was tapered off. Of those, five patients remained in remission by maxacalcitol ointment for over 12 months and three patients for 6 months. In conclusion, this preliminary study may suggest that supplementary therapy of short-term CyA MEPC administration in combination with topical vitamin D3 treatment may be worth trying for patients with moderate psoriasis vulgaris.

• Authors: Masatoshi Abe, Tomoko Syuto, Michiko Hasegawa, Yoko Yokoyama, Osamu Ishikawa
• Journal: The Journal of dermatology (J Dermatol) Vol. 36 Issue 4 Pg. 197-201 (Apr 2009) ISSN: 1346-8138 [Electronic] England
• PMID: 19348657 (Publication Type: Journal Article)

Chemical References

• Dermatologic Agents
• Ointments
• Cyclosporine
• Calcitriol
• maxacalcitol

Topics

• Administration, Topical
• Adult
• Calcitriol (administration & dosage, analogs & derivatives)
• Cyclosporine (administration & dosage)
• Dermatologic Agents (administration & dosage)
• Drug Synergism
• Female
• Humans
• Male
• Ointments
• Patient Satisfaction
• Psoriasis (drug therapy, pathology)
• Remission Induction