Cerebral perfusion abnormalities in therapy-resistant epilepsy in mentally retarded pediatric patients. Comparison between EEG, X-ray CT, and Tc-99m HMPAO.

Abstract

Thirteen mentally retarded pediatric patients aged 4 to 13 years with therapy-resistant epilepsy underwent Tc-99m HMPAO brain perfusion SPECT studies. The results (abnormal in 12 of the 13 patients) were compared with EEG results in 12 of the 13 patients (abnormal in all 12) and x-ray CT in 11 of the 13 patients (normal in 9). Patients with spikes on EEG had foci of increased uptake on HMPAO. This study confirms that HMPAO is sensitive in detecting perfusion abnormalities and localizing epileptic foci in this group of patients.

• Authors: H M Abdel-Dayem, M K Nawaz, M M Hassoon, M Abdel-Rahman, O E Olofsson
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 16 Issue 8 Pg. 557-61 (Aug 1991) ISSN: 0363-9762 [Print] United States
• PMID: 1934807 (Publication Type: Case Reports, Comparative Study, Journal Article)

Chemical References

• Organotechnetium Compounds
• Oximes
• Technetium Tc 99m Exametazime

Topics

• Brain (diagnostic imaging)
• Cerebrovascular Circulation (physiology)
• Child
• Electroencephalography
• Epilepsy (complications, diagnosis, diagnostic imaging)
• Female
• Humans
• Intellectual Disability (complications)
• Male
• Organotechnetium Compounds
• Oximes
• Technetium Tc 99m Exametazime
• Tomography, Emission-Computed, Single-Photon
• Tomography, X-Ray Computed