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Evaluation of leishmanin skin test in Indian visceral leishmaniasis.

Abstract
We evaluated the performance of the leishmanin skin test (LST) in 50 patients with visceral leishmaniasis (VL), 124 cured VL patients at different time intervals, 125 healthy controls from an endemic region (HEC), and 14 healthy controls from a non-endemic region (NEHC). The leishmanin antigen used was based on Leishmania major and was obtained from the Pasteur Institute (Iran). A positive LST was found in 14.0% of patients with active VL, 40.3% of cured patients, 21.6% of HECs, and 0% in NEHCs. The 14% positivity in patients with active VL conflicts with the widely held opinion that such patients should be negative because of anergy. Also, a lack of sensitivity of the LST was observed in cured VL patients. An LST antigen produced from L. donovani strains from India should be explored.
AuthorsKamlesh Gidwani, Madhukar Rai, Jaya Chakravarty, Marleen Boelaert, Shyam Sundar
JournalThe American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 80 Issue 4 Pg. 566-7 (Apr 2009) ISSN: 1476-1645 [Electronic] United States
PMID19346376 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antigens, Protozoan
  • Antiprotozoal Agents
  • leishmanin
Topics
  • Antigens, Protozoan (immunology)
  • Antiprotozoal Agents (therapeutic use)
  • Humans
  • India (epidemiology)
  • Leishmaniasis, Visceral (diagnosis, drug therapy, epidemiology, immunology)
  • Skin Tests
  • Time Factors

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