Abstract | BACKGROUND: METHODS: RESULTS: With a median follow-up of 29 months for survivors (range, 14-39), the 3-year local progression-free, regional progression-free, and distant metastasis-free survival rates were 89.6%, 87.2%, and 80.4%, respectively. Treatment was well tolerated despite the grade 3 mucositis (16%) and/or pharyngitis (16%). With follow-up, the frequency of xerostomia decreased. At 3 months after IMRT, the proportions of Radiation Therapy Oncology Group grades 0, 1, and 2 xerostomia were 13%, 38%, and 50%, respectively. At 24 months, the corresponding figures were 36%, 46%, and 18%, respectively. CONCLUSION: IMRT with SIB technique for locoregionally advanced NPC was feasible and effective regarding locoregional control and development of xerostomia, even after neoadjuvant chemotherapy. Definition of gross tumor volume by postchemotherapy extent of disease was also feasible.
|
Authors | Kyubo Kim, Hong-Gyun Wu, Hak Jae Kim, Myung-Whun Sung, Kwang Hyun Kim, Se-Hoon Lee, Dae Seog Heo, Hee Jung Kim, Charn Il Park |
Journal | Head & neck
(Head Neck)
Vol. 31
Issue 9
Pg. 1121-8
(Sep 2009)
ISSN: 1097-0347 [Electronic] United States |
PMID | 19340863
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Central Nervous System
(radiation effects)
- Disease-Free Survival
- Female
- Humans
- Male
- Middle Aged
- Nasopharyngeal Neoplasms
(drug therapy, pathology, radiotherapy)
- Neoadjuvant Therapy
- Radiation Dosage
- Radiotherapy Dosage
- Radiotherapy, Intensity-Modulated
(adverse effects)
- Young Adult
|