Very late drug-eluting stent thrombosis after nonsteroidal anti-inflammatory drug treatment despite dual antiplatelet therapy.

Abstract

BACKGROUND:

Drug-eluting coronary stent implantation emerged as a safe and effective therapeutic approach by preventing coronary restenosis and reducing the need for further revascularization. However, in contrast to bare metal stents, recent data suggest a unique underlying pathology, namely late coronary stent thrombosis and delayed endothelial healing.

OBJECTIVE:

To report a case of very late coronary stent thrombosis (834 days after implantation) requiring repeat urgent target-vessel revascularization. Importantly, six days before the acute coronary event, combined nonsteroidal anti-inflammatory drug therapy was initiated.

RESULTS:

Although a dual antiplatelet regimen was continuously maintained, aggregation measurements indicated only partial antiplatelet effect, which returned to the expected range when nonsteroidal anti-inflammatory drugs were omitted.

CONCLUSIONS:

The observation indicates that, even 834 days after drug-eluting stent implantation, effective combined antiplatelet therapy might be crucial in certain individuals and the possible impact of drug interactions should not be underestimated. Further efforts should focus on the challenging task of identifying patients or medical situations with prolonged, increased risk of stent thrombosis.

• Authors: Bela Merkely, Emese Tóth-Zsamboki, David Becker, Bernat Janos Beres, György Szabó, Katarina Vargova, Gabor Fülöp, Gabor Kerecsen, Istvan Preda, Christian Spaulding, Robert G Kiss
• Journal: The Canadian journal of cardiology (Can J Cardiol) Vol. 25 Issue 4 Pg. 229-32 (Apr 2009) ISSN: 1916-7075 [Electronic] England
• PMID: 19340348 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cyclooxygenase Inhibitors
• Platelet Aggregation Inhibitors
• Thiazines
• Thiazoles
• Diclofenac
• Clopidogrel
• Ticlopidine
• Aspirin
• Meloxicam

Topics

• Adult
• Angioplasty, Balloon, Coronary
• Aspirin (administration & dosage)
• Clopidogrel
• Coronary Thrombosis (etiology, physiopathology, prevention & control)
• Cyclooxygenase Inhibitors (administration & dosage, adverse effects)
• Diabetic Angiopathies (therapy)
• Diclofenac (administration & dosage, adverse effects)
• Drug Interactions
• Drug-Eluting Stents (adverse effects)
• Endothelium, Vascular (drug effects, physiopathology)
• Humans
• Intervertebral Disc Displacement (drug therapy)
• Male
• Meloxicam
• Myocardial Infarction (therapy)
• Platelet Aggregation (drug effects, physiology)
• Platelet Aggregation Inhibitors (administration & dosage)
• Thiazines (administration & dosage, adverse effects)
• Thiazoles (administration & dosage, adverse effects)
• Ticlopidine (administration & dosage, analogs & derivatives)
• Time Factors