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Chromoblastomycosis: combined treatment with pulsed itraconazole therapy and liquid nitrogen cryotherapy.

AbstractBACKGROUND:
Three patients with histology- and culture-proven chromoblastomycosis reported to the Colombo South Teaching Hospital, Sri Lanka, in 2005. All three were men (age range, 48-53 years). The duration of symptoms varied from 1 to 8 years and the lesions were on the lower limbs.
METHODS:
The patients were treated simultaneously with liquid nitrogen cryotherapy and itraconazole pulses, i.e. 200 mg twice daily for 7 days per month, 1 week on and 3 weeks off. Cryotherapy was given every fortnight using large cotton swabs attached to ekels or the cryogun.
RESULTS:
Two patients showed a good clinical response within 4 months, with negative histopathology and culture in 4-6 months. The third patient was very resistant to treatment and needed a step-up of the itraconazole dose.
CONCLUSION:
A combination of fortnightly liquid nitrogen cryotherapy and pulsed monthly itraconazole is cost-effective and shortens the duration of therapy compared with the use of itraconazole or cryotherapy alone.
AuthorsRanthilaka R Ranawaka, Nishan Amarasinghe, Dantha Hewage
JournalInternational journal of dermatology (Int J Dermatol) Vol. 48 Issue 4 Pg. 397-400 (Apr 2009) ISSN: 1365-4632 [Electronic] England
PMID19335426 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Antifungal Agents
  • Itraconazole
  • Nitrogen
Topics
  • Antifungal Agents (administration & dosage)
  • Chromoblastomycosis (drug therapy, pathology)
  • Combined Modality Therapy
  • Cryotherapy (methods)
  • Humans
  • Itraconazole (administration & dosage)
  • Male
  • Middle Aged
  • Nitrogen
  • Prospective Studies
  • Treatment Outcome

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