Abstract | BACKGROUND: Three patients with histology- and culture-proven chromoblastomycosis reported to the Colombo South Teaching Hospital, Sri Lanka, in 2005. All three were men (age range, 48-53 years). The duration of symptoms varied from 1 to 8 years and the lesions were on the lower limbs. METHODS: The patients were treated simultaneously with liquid nitrogen cryotherapy and itraconazole pulses, i.e. 200 mg twice daily for 7 days per month, 1 week on and 3 weeks off. Cryotherapy was given every fortnight using large cotton swabs attached to ekels or the cryogun. RESULTS: Two patients showed a good clinical response within 4 months, with negative histopathology and culture in 4-6 months. The third patient was very resistant to treatment and needed a step-up of the itraconazole dose. CONCLUSION:
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Authors | Ranthilaka R Ranawaka, Nishan Amarasinghe, Dantha Hewage |
Journal | International journal of dermatology
(Int J Dermatol)
Vol. 48
Issue 4
Pg. 397-400
(Apr 2009)
ISSN: 1365-4632 [Electronic] England |
PMID | 19335426
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antifungal Agents
- Itraconazole
- Nitrogen
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Topics |
- Antifungal Agents
(administration & dosage)
- Chromoblastomycosis
(drug therapy, pathology)
- Combined Modality Therapy
- Cryotherapy
(methods)
- Humans
- Itraconazole
(administration & dosage)
- Male
- Middle Aged
- Nitrogen
- Prospective Studies
- Treatment Outcome
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