HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A case of Brucella spondylitis in a patient with psoriatic arthritis receiving infliximab.

Abstract
A 69-year-old woman with psoriatic arthritis treated with infliximab presented with low back pain of recent onset and fever. Serological, microbiological and imaging studies revealed Brucella spondylitis at the L5-S1 level. Immunosuppressive therapy was suspended and antibiotic therapy including doxycycline and rifampicin was administered for six months. The patient responded adequately with clinical and laboratory improvement and a considerable remission of spondylitis on repeat magnetic resonance imaging scan. The pathophysiology of tumor necrosis factor (TNF) alpha in Brucellosis and the role of anti-TNFalpha therapy are discussed.
AuthorsC E Papagoras, M I Argyropoulou, P V Voulgari, I Vrabie, A K Zikou, A A Drosos
JournalClinical and experimental rheumatology (Clin Exp Rheumatol) 2009 Jan-Feb Vol. 27 Issue 1 Pg. 124-7 ISSN: 0392-856X [Print] Italy
PMID19327241 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Antibodies, Monoclonal
  • Tumor Necrosis Factor-alpha
  • Infliximab
  • Doxycycline
  • Rifampin
Topics
  • Aged
  • Anti-Bacterial Agents (therapeutic use)
  • Antibodies, Monoclonal (adverse effects)
  • Arthritis, Psoriatic (drug therapy)
  • Brucellosis (diagnosis, drug therapy, immunology)
  • Doxycycline (therapeutic use)
  • Drug Therapy, Combination
  • Female
  • Humans
  • Immunity, Innate (immunology)
  • Infliximab
  • Rifampin (therapeutic use)
  • Spondylitis (microbiology)
  • Tumor Necrosis Factor-alpha (antagonists & inhibitors, immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: