Abstract |
Surgical resection is the first-choice therapy for extramammary Paget's disease, but extensive resection is highly invasive and non-surgical treatments are sometimes preferred. Although photodynamic therapy ( PDT) has been used for extramammary Paget's disease for some time, recurrence and residual tumour cells are common. In the present study, five patients with extramammary Paget's disease with a total of eight lesions first underwent carbon dioxide ( CO2) laser abrasion, followed by 3 h of occlusive application of aminolaevulinic acid (ALA) and then 100 J/cm2 irradiation with a 630-nm excimer dye laser. This combination treatment regime was repeated every 2 weeks for a total of 3 times. Group 1 comprised two patients (five lesions) who received CO2 laser and ALA- PDT only. Group 2 comprised three patients (three lesions) who received CO2 laser and ALA- PDT for residual tumour cells following surgery. Follow-up examinations showed that seven lesions in five patients had not recurred after 12 months, suggesting the efficacy of the present method.
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Authors | Toshimitsu Fukui, Daisuke Watanabe, Yasuhiko Tamada, Yoshinari Matsumoto |
Journal | Acta dermato-venereologica
(Acta Derm Venereol)
Vol. 89
Issue 2
Pg. 150-4
( 2009)
ISSN: 0001-5555 [Print] Sweden |
PMID | 19325999
(Publication Type: Journal Article)
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Chemical References |
- Photosensitizing Agents
- Aminolevulinic Acid
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Topics |
- Aged
- Aged, 80 and over
- Aminolevulinic Acid
(therapeutic use)
- Combined Modality Therapy
- Female
- Humans
- Lasers, Excimer
- Lasers, Gas
- Low-Level Light Therapy
- Male
- Paget Disease, Extramammary
(drug therapy, radiotherapy, therapy)
- Penile Neoplasms
(drug therapy, radiotherapy, therapy)
- Photochemotherapy
- Photosensitizing Agents
(therapeutic use)
- Skin Neoplasms
(drug therapy, radiotherapy, therapy)
- Vulvar Neoplasms
(drug therapy, radiotherapy, therapy)
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