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Photodynamic therapy following carbon dioxide laser enhances efficacy in the treatment of extramammary Paget's disease.

Abstract
Surgical resection is the first-choice therapy for extramammary Paget's disease, but extensive resection is highly invasive and non-surgical treatments are sometimes preferred. Although photodynamic therapy (PDT) has been used for extramammary Paget's disease for some time, recurrence and residual tumour cells are common. In the present study, five patients with extramammary Paget's disease with a total of eight lesions first underwent carbon dioxide (CO2) laser abrasion, followed by 3 h of occlusive application of aminolaevulinic acid (ALA) and then 100 J/cm2 irradiation with a 630-nm excimer dye laser. This combination treatment regime was repeated every 2 weeks for a total of 3 times. Group 1 comprised two patients (five lesions) who received CO2 laser and ALA-PDT only. Group 2 comprised three patients (three lesions) who received CO2 laser and ALA-PDT for residual tumour cells following surgery. Follow-up examinations showed that seven lesions in five patients had not recurred after 12 months, suggesting the efficacy of the present method.
AuthorsToshimitsu Fukui, Daisuke Watanabe, Yasuhiko Tamada, Yoshinari Matsumoto
JournalActa dermato-venereologica (Acta Derm Venereol) Vol. 89 Issue 2 Pg. 150-4 ( 2009) ISSN: 0001-5555 [Print] Sweden
PMID19325999 (Publication Type: Journal Article)
Chemical References
  • Photosensitizing Agents
  • Aminolevulinic Acid
Topics
  • Aged
  • Aged, 80 and over
  • Aminolevulinic Acid (therapeutic use)
  • Combined Modality Therapy
  • Female
  • Humans
  • Lasers, Excimer
  • Lasers, Gas
  • Low-Level Light Therapy
  • Male
  • Paget Disease, Extramammary (drug therapy, radiotherapy, therapy)
  • Penile Neoplasms (drug therapy, radiotherapy, therapy)
  • Photochemotherapy
  • Photosensitizing Agents (therapeutic use)
  • Skin Neoplasms (drug therapy, radiotherapy, therapy)
  • Vulvar Neoplasms (drug therapy, radiotherapy, therapy)

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