Abstract |
Acute lymphoblastic leukemia (ALL), a primary hematologic malignancy that is especially common in childhood, occurs relatively rarely as a secondary malignant neoplasm. Available data indicate that ALL often follows chemoradiotherapy for soft tissue sarcoma. Perivascular epithelioid tumor ( PEComa), a primitive mesenchymal tissue origin, can be classified as a soft tissue sarcoma. An 11-year-old girl was diagnosed with ALL secondary to chemoradiotherapy ( vincristine, ifosfamide, and anthracycline) and radiotherapy comprising 45 Gy to the whole pelvis for PEComa. ALL, FAB L2, and immunophenotypically pro-B developed 16 months after the final chemotherapy treatment. Moreover, a cytogenetic study of lymphoblasts showed t(1;11)(p32;q23). Herein, the authors report a case of secondary ALL that might be related to a previously used intercalating DNA topoisomerase II inhibitor ( anthracycline) for a very rare sarcoma, PEComa.
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Authors | In-sang Jeon, Dae Yong Yi |
Journal | Pediatric hematology and oncology
(Pediatr Hematol Oncol)
Vol. 26
Issue 2
Pg. 85-8
(Mar 2009)
ISSN: 1521-0669 [Electronic] England |
PMID | 19322738
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Anthracyclines
- Topoisomerase II Inhibitors
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Topics |
- Anthracyclines
(adverse effects)
- Child
- Cytogenetic Analysis
- Female
- Humans
- Neoplasms, Second Primary
(etiology, genetics)
- Perivascular Epithelioid Cell Neoplasms
(complications, drug therapy, radiotherapy)
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(etiology, genetics)
- Precursor Cells, B-Lymphoid
(pathology)
- Topoisomerase II Inhibitors
- Translocation, Genetic
- Uterine Neoplasms
(complications, drug therapy, radiotherapy)
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