Abstract | BACKGROUND: The practice of platelet (PLT) transfusions has been adopted into the standard clinical practice in many dengue-endemic countries. Because many patients were found to have received unnecessary PLT transfusions, the development of guidelines for the management of dengue patients with thrombocytopenia has become a necessity. STUDY DESIGN AND METHODS: An emergency department-based prospective observational study was conducted in Martinique during a dengue outbreak in adult patients presenting with an acute febrile illness. Patients with severe bleeding and/or who underwent invasive intensive care procedures or emergency surgery were given PLT transfusion to achieve PLT counts of more than 50 x 10(9)/L. PLT transfusion was also considered for patients with PLT counts of less than 5 x 10(9)/L and for those with associated risk factors and PLT counts of less than 20 x 10(9)/L. RESULTS: A total of 350 patients were admitted with confirmed dengue infections. Most of them had secondary serotype-2 infections. PLT counts of less than 50 x 10(9)/L were recorded in 165 patients (47.1%). PLT transfusion was administered to 9 patients with thrombocytopenia. The indications included severe bleeding (5 cases), invasive procedures (3 cases), emergency surgery (1 case), and/or associated risk factors (2 cases). The median time duration from the onset of fever to PLT transfusion was 6 days (range, 4-10 days). The median amount of PLTs transfused was 3.66 x 10(11) (range, 2.8 x 10(11)-13.2 x 10(11)). The median PLT yield was +12.4% (range, -3.9% to +67.1%). Three patients died. All other patients recovered during the second week after the onset of fever. CONCLUSION: A restrictive strategy for PLT transfusion based on clinical features and low PLT count thresholds proved to be feasible and safe for adult dengue patients.
|
Authors | Laurent Thomas, Stéphane Kaidomar, Brigitte Kerob-Bauchet, Victor Moravie, Yannick Brouste, Jean Philippe King, Sarah Schmitt, François Besnier, Sylvie Abel, Hossein Mehdaoui, Yves Plumelle, Fatiha Najioullah, Christiane Fonteau, Pascale Richard, Raymond Césaire, André Cabié |
Journal | Transfusion
(Transfusion)
Vol. 49
Issue 7
Pg. 1400-11
(Jul 2009)
ISSN: 1537-2995 [Electronic] United States |
PMID | 19320862
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Dengue
(therapy)
- Female
- Humans
- Male
- Middle Aged
- Platelet Count
- Platelet Transfusion
(adverse effects, methods)
- Prospective Studies
- Young Adult
|