Streptococcus mitis endophthalmitis presenting as frosted branch angiitis after intravitreal pegaptanib sodium injection.

Abstract

An 80-year-old woman presented with endophthalmitis and a frosted branch angiitis-like picture following intravitreal injection of pegaptanib sodium for age-related macular degeneration. After vitreous tap and injection of antibiotics, the patient underwent vitrectomy because her clinical condition worsened. Cultures grew Streptococcus mitis, and the patient's visual acuity stabilized at hand motions following unsuccessful repair of a retinal detachment complicated by proliferative vitreoretinopathy. Because S. mitis can cause an endophthalmitis that presents as frosted branch angiitis, it must be considered in the differential diagnosis of patients who present with frosted branch angiitis.

• Authors: Eric Chen, Allen C Ho, Sunir J Garg, Gary C Brown, Richard S Kaiser
• Journal: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye (Ophthalmic Surg Lasers Imaging) 2009 Mar-Apr Vol. 40 Issue 2 Pg. 192-4 ISSN: 1542-8877 [Print] United States
• PMID: 19320312 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Aptamers, Nucleotide
• Vascular Endothelial Growth Factor A
• pegaptanib

Topics

• Aged, 80 and over
• Anti-Bacterial Agents (therapeutic use)
• Aptamers, Nucleotide (administration & dosage)
• Combined Modality Therapy
• Endophthalmitis (diagnosis, etiology, therapy)
• Eye Infections, Bacterial (diagnosis, etiology, therapy)
• Female
• Fluorescein Angiography
• Humans
• Injections (adverse effects)
• Macular Degeneration (drug therapy)
• Retinal Vasculitis (diagnosis, etiology, therapy)
• Streptococcal Infections (diagnosis, etiology, therapy)
• Streptococcus mitis (isolation & purification)
• Vascular Endothelial Growth Factor A (antagonists & inhibitors)
• Vitrectomy
• Vitreous Body (microbiology)