Products of lipid peroxidation and changes in sulfhydryl compounds in pancreatic tissue of rats with caerulein-induced acute pancreatitis.

Abstract

Acute edematous pancreatitis was induced in rats by iv infusion of caerulein (CR) in a supramaximal dose of 7.5 x 10(-6)g x kg-1 x hr-1 during 6 hr. The most important finding of our study was the marked decrease of protein and nonprotein thiol content in pancreatic tissue of rats with CR-induced acute pancreatitis (AP). Oxygen radicals as well as 4-hydroxyalkenals resulting from lipid peroxidation are believed to be at least partly responsible for this phenomenon. Covalent binding of excessive amounts of 4-hydroxyalkenals to pancreatic tissue protein sulfhydryl groups has been documented. Presented data suggest a serious disturbance of sulfhydryl compounds metabolism in pancreatic tissue of rats with CR-induced AP which may be of importance in the pathogenesis of the disease.

• Authors: A Dabrowski, A Gabryelewicz, M Chwiećko
• Journal: Biochemical medicine and metabolic biology (Biochem Med Metab Biol) Vol. 46 Issue 1 Pg. 10-6 (Aug 1991) ISSN: 0885-4505 [Print] United States
• PMID: 1931150 (Publication Type: Journal Article)

Chemical References

• Free Radicals
• Proteins
• Sulfhydryl Compounds
• Ceruletide

Topics

• Acute Disease
• Animals
• Ceruletide
• Free Radicals
• Lipid Peroxidation
• Male
• Pancreas (metabolism)
• Pancreatitis (chemically induced, metabolism)
• Proteins (metabolism)
• Rats
• Rats, Inbred Strains
• Sulfhydryl Compounds (metabolism)