Abstract | AIMS: In skull base chordoma, c-MET expression has been reported to correlate with younger patient age and favourable prognosis; however, it also contributes to tumour invasiveness, especially in recurrent lesions, suggesting variable roles for c-MET according to clinical status. The aim of this study was to investigate the significance of c-MET expression in spinal chordoma, which affects patients who are 10-20 years older than those with skull base chordoma. METHODS AND RESULTS: Using immunohistochemical techniques, the expression of c-MET and its ligand, hepatocyte growth factor (HGF) was investigated in 34 primary spinal chordomas and compared with other clinicopathological parameters. Expression of c-MET and HGF was observed in 85.3 and 21.7% of lesions, respectively. c-MET expression correlated with the expression of an epithelial marker, low-molecular-weight cytokeratin ( CAM5.2). Lesions with higher c-MET expression showed significantly stronger expression of proteinases, including matrix metalloproteinase (MMP)-1 and MMP-2. However, c-MET expression was not associated with patient age, proliferative ability estimated by MIB-1 labelling index, or prognosis. CONCLUSIONS: c-MET expression was observed in most spinal chordomas and correlated with the expression of CAM5.2, suggesting a relationship to an epithelial phenotype.
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Authors | Takahiko Naka, Carsten Boltze, Amir Samii, Madjid Samii, Christian Herold, Helmut Ostertag, Yukihide Iwamoto, Yoshinao Oda, Masazumi Tsuneyoshi, Doerthe Kuester, Albert Roessner |
Journal | Histopathology
(Histopathology)
Vol. 54
Issue 5
Pg. 607-13
(Apr 2009)
ISSN: 1365-2559 [Electronic] England |
PMID | 19302530
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Biomarkers, Tumor
- CAM 5.2 antigen
- Hepatocyte Growth Factor
- Keratins
- Proto-Oncogene Proteins c-met
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 1
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
- Biomarkers, Tumor
(analysis)
- Chordoma
(metabolism, mortality, pathology)
- Female
- Hepatocyte Growth Factor
(biosynthesis)
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Keratins
(biosynthesis)
- Male
- Matrix Metalloproteinase 1
(biosynthesis)
- Matrix Metalloproteinase 2
(biosynthesis)
- Middle Aged
- Prognosis
- Proto-Oncogene Proteins c-met
(biosynthesis)
- Spinal Cord Neoplasms
(metabolism, mortality, pathology)
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