Fluorescein angiography and visual acuity in active uveitis with Behçet disease.

Abstract

PURPOSE:

To determine the association of fluorescein angiography characteristics with visual acuity and visual loss during medical treatment in patients with Behçet uveitis.

METHODS:

Ninety-three eyes from 69 Behçet patients with active panuveitis underwent fluorescein angiography, and the characteristic findings by angiography were determined. The patients were followed with immunomodulatory treatment.

RESULTS:

Diffuse vascular leakage (73.4%), diffuse macular leakage (66.0%), and disc leakage (52.7%) were the predominant angiographic findings on fluorescein angiography. Multivariate logistic regression analysis revealed that a macular window defect and disc neovascularization on fluorescein angiography were associated with poor visual acuity (<or= 20/200) (p < .05). The presence of macular ischemia on fluorescein angiography was significantly associated with the risk of visual loss (<or= 20/200) at 48 months post-treatment (p < .05).

CONCLUSIONS:

These results suggest that fluorescein angiography may be helpful for predicting visual prognosis for Behçet patients with panuveitis.

• Authors: Hyeong Gon Yu, Moon Jung Kim, Frederick Sewoong Oh
• Journal: Ocular immunology and inflammation (Ocul Immunol Inflamm) 2009 Jan-Feb Vol. 17 Issue 1 Pg. 41-6 ISSN: 1744-5078 [Electronic] England
• PMID: 19294573 (Publication Type: Journal Article)

Chemical References

• Immunosuppressive Agents

Topics

• Adult
• Aged
• Behcet Syndrome (diagnosis, drug therapy, physiopathology)
• Female
• Fluorescein Angiography
• Follow-Up Studies
• Humans
• Immunosuppressive Agents (therapeutic use)
• Male
• Middle Aged
• Panuveitis (diagnosis, drug therapy, physiopathology)
• Retrospective Studies
• Risk Factors
• Vision Disorders (physiopathology)
• Visual Acuity (physiology)
• Young Adult