In vivo magnetic resonance spectroscopy of brain and muscle in a type of mitochondrial encephalomyopathy (MERRF).

Abstract

Phosphorus magnetic resonance spectroscopy allows noninvasive measurement of the intracellular phosphate-containing metabolites and intracellular pH in localized volumes of human muscle and brain in vivo. This technique was used to study 8 patients with a mitochondrial cytopathy (myoclonus epilepsy with ragged red fibers). Phosphorus magnetic resonance spectroscopy of resting gastrocnemius muscle demonstrated significantly increased relative intracellular inorganic phosphate concentrations (p less than 0.0005) and decreased phosphocreatine to inorganic phosphate concentration ratios (p less than 0.01) in the patients, although only 3 had myopathic signs or symptoms. We propose, therefore, that phosphorus magnetic resonance spectroscopy of resting skeletal muscle is a useful clinical test in evaluation of progressive myoclonus epilepsy. In contrast to results from muscle, however, the relative phosphate metabolite concentrations and intracellular pH in central volumes of the brains of these patients were normal, despite evidence from our previous positron emission tomography studies suggesting that there is diffuse impairment of cerebral oxidative metabolism.

• Authors: P M Matthews, S F Berkovic, E A Shoubridge, F Andermann, G Karpati, S Carpenter, D L Arnold
• Journal: Annals of neurology (Ann Neurol) Vol. 29 Issue 4 Pg. 435-8 (Apr 1991) ISSN: 0364-5134 [Print] United States
• PMID: 1929212 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Phosphorus

Topics

• Brain (metabolism, pathology)
• Epilepsies, Myoclonic (metabolism, pathology)
• Humans
• Magnetic Resonance Imaging
• Magnetic Resonance Spectroscopy
• Mitochondria, Muscle (metabolism)
• Muscles (metabolism)
• Phosphorus (metabolism)