In Vitro activity of terbinafine combined with caspofungin and azoles against Pythium insidiosum.

Abstract

In this text we evaluated the in vitro antifungal activities of terbinafine combined with caspofungin, miconazole, ketoconazole, and fluconazole against 17 Pythium insidiosum strains by using the microdilution checkerboard method. Synergistic interactions were observed with terbinafine combined with caspofungin (41.2% of the strains), fluconazole (41.2%), ketoconazole (29.4%), and miconazole (11.8%). No antagonistic effects were observed. The combination of terbinafine plus caspofungin or terbinafine plus fluconazole may have significant therapeutic potential for treatment of pythiosis.

• Authors: Ayrton S Cavalheiro, Grazieli Maboni, Maria I de Azevedo, Juliana S Argenta, Daniela I B Pereira, Tatiana B Spader, Sydney H Alves, Janio M Santurio
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 53 Issue 5 Pg. 2136-8 (May 2009) ISSN: 1098-6596 [Electronic] United States
• PMID: 19289531 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Azoles
• Echinocandins
• Lipopeptides
• Naphthalenes
• Caspofungin
• Terbinafine

Topics

• Animals
• Antifungal Agents (classification, pharmacology)
• Azoles (pharmacology)
• Brazil
• Caspofungin
• Drug Interactions
• Drug Synergism
• Drug Therapy, Combination
• Echinocandins (pharmacology)
• Horse Diseases (microbiology)
• Horses
• Infections (microbiology)
• Lipopeptides
• Microbial Sensitivity Tests (methods)
• Naphthalenes (pharmacology)
• Pythium (classification, drug effects, isolation & purification)
• Terbinafine