Abstract | OBJECTIVES: In this study, we prospectively compared the use of endoscopic retrograde cholangiopancreatography (ERCP), endoscopic ultrasonography (EUS), and fecal elastase 1 in patients with chronic pancreatitis and searched for correlation with symptoms, clinical findings, and elastase 1 levels. METHODS: Twenty-four consecutive patients (19 were male, and 5 were female) with chronic pancreatitis who had already undergone ERCP within the last 2 years and 19 healthy control subjects (10 were male, and 9 were female) are studied prospectively. Clinical and laboratory parameters of the patients were recorded, and all underwent EUS and fecal elastase 1 testing. Fecal elastase 1 was measured in healthy control subjects. RESULTS: The ERCP and EUS severity scores were 1 in 0 to 2 patients, 2 in 6 to 8 patients, and 3 in 18 to 14 patients. Sensitivity and specificity of fecal elastase for chronic pancreatitis were 75% and 100%, respectively. There was a negative correlation between disease duration and fecal elastase 1 levels. Patients with dyspepsia or those who use pancreatic enzyme preparations had significantly lower fecal elastase 1 levels than others. CONCLUSIONS: Endoscopic retrograde cholangiopancreatography and EUS are nearly equal in staging chronic pancreatitis. Fecal elastase 1 correlates well with these tests. Fecal elastase 1 also correlates well with some clinical symptoms such as dyspepsia and disease history.
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Authors | Oğuz Usküdar, Dilek Oğuz, Meral Akdoğan, Emin Altiparmak, Burhan Sahin |
Journal | Pancreas
(Pancreas)
Vol. 38
Issue 5
Pg. 503-6
(Jul 2009)
ISSN: 1536-4828 [Electronic] United States |
PMID | 19287334
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adult
- Cholangiopancreatography, Endoscopic Retrograde
- Dyspepsia
(diagnosis, enzymology)
- Endosonography
- Feces
(enzymology)
- Female
- Humans
- Male
- Middle Aged
- Pancreas
(enzymology, pathology)
- Pancreatic Elastase
(metabolism)
- Pancreatitis, Chronic
(diagnosis, enzymology)
- Prospective Studies
- Sensitivity and Specificity
- Severity of Illness Index
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