Abstract | PURPOSE: METHODS: RESULTS: The polycarbophil-based ophthalmic delivery system, DuraSite (InSite Vision, Alameda, CA), helps solubilize azithromycin and retard its degradation in aqueous solution. The formulation was stable at room temperature as well as 5 degrees C. Upon administration of a single drop of 1% azithromycin in DuraSite ophthalmic solution in rabbits' eyes, tear concentrations of azithromycin ranged from 87 to 288 microg/g and high concentrations were sustained for over a 24-h period. CONCLUSIONS:
Azithromycin can be developed as an eyedrop in an aqueous ocular delivery system for the treatment of ocular surface infections. The ocular delivery system, DuraSite solubilizes azithromycin at a high concentration in an aqueous solution and protects it from degradation during manufacture and storage. The development of azithromycin in this delivery system enhances the antibiotic's usefulness in ophthalmology for the topical treatment of ocular surface bacterial infections and lid margin diseases.
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Authors | Lyle M Bowman, Erwin Si, Joseph Pang, Roy Archibald, Mitchell Friedlaender |
Journal | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
(J Ocul Pharmacol Ther)
Vol. 25
Issue 2
Pg. 133-9
(Apr 2009)
ISSN: 1557-7732 [Electronic] United States |
PMID | 19284320
(Publication Type: Journal Article)
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Chemical References |
- Acrylic Resins
- Anti-Bacterial Agents
- Drug Carriers
- Ophthalmic Solutions
- Azithromycin
- calcium polycarbophil
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Topics |
- Acrylic Resins
- Adhesiveness
- Administration, Topical
- Animals
- Anti-Bacterial Agents
(administration & dosage, pharmacokinetics)
- Azithromycin
(administration & dosage, pharmacokinetics)
- Biological Availability
- Drug Carriers
- Drug Stability
- Ophthalmic Solutions
- Rabbits
- Solubility
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