Antibacterial effectiveness of ciprofloxacin 0.3% ophthalmic solution in the treatment of bacterial conjunctivitis.

Abstract

Two hundred eighty-eight cases of culture-proven bacterial conjunctivities were evaluated as part of two multicentered, randomized, prospective clinical studies comparing the antibacterial efficacy of topically administered ciprofloxacin 0.3% either with a placebo or with tobramycin 0.3%. In the first study, ciprofloxacin was significantly (P less than .001) more effective than the placebo. It eradicated or reduced the various bacterial pathogens in 93.6% of patients, compared to 59.5% for the placebo. In the second study, ciprofloxacin (94.5%) and tobramycin (91.9%) were equally effective. Topically applied ciprofloxacin eradicated or reduced all isolated bacterial species, attesting to its broad antibacterial spectrum and its potential usefulness in treating external ocular infections.

• Authors: H M Leibowitz
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 112 Issue 4 Suppl Pg. 29S-33S (Oct 1991) ISSN: 0002-9394 [Print] United States
• PMID: 1928271 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Ophthalmic Solutions
• Ciprofloxacin
• Tobramycin

Topics

• Anti-Bacterial Agents (therapeutic use)
• Bacteria (drug effects, isolation & purification)
• Bacterial Infections (drug therapy)
• Ciprofloxacin (administration & dosage, therapeutic use)
• Conjunctivitis (drug therapy, microbiology)
• Humans
• Ophthalmic Solutions
• Prospective Studies
• Tobramycin (therapeutic use)