Four successful pregnancies in a patient with mucopolysaccharidosis type I treated by allogeneic bone marrow transplantation.

Abstract

To date, little is known about the fertility of women suffering from mucopolysaccharidosis type I (MPS I). We report on a female patient with MPS I treated by allogeneic bone marrow transplantation (BMT) at the age of 4 years (after a conditioning regimen containing busulfan 16 mg/kg and cyclophosphamide 100 mg/kg) who had four successful pregnancies without any reproductive assistance. Clinical and biological examinations of the children were normal. On the basis of this case, we discuss the fertility counselling of female MPS I patients at the time of BMT.

• Authors: G Remérand, E Merlin, R Froissart, F Brugnon, J Kanold, L Janny, F Deméocq
• Journal: Journal of inherited metabolic disease (J Inherit Metab Dis) Vol. 32 Suppl 1 Pg. S111-3 (Dec 2009) ISSN: 1573-2665 [Electronic] United States
• PMID: 19280364 (Publication Type: Case Reports, Journal Article)

Topics

• Adolescent
• Adult
• Bone Marrow Transplantation
• Child, Preschool
• Female
• Genetic Counseling
• Humans
• Infant, Newborn
• Mucopolysaccharidosis I (complications, genetics, therapy)
• Pregnancy
• Pregnancy Complications (genetics)
• Pregnancy Outcome
• Young Adult