The search for an ideal temporary skin substitute: AWBAT.

Abstract

OBJECTIVE:

The search for an ideal temporary skin substitute is a continuous quest. Without the ability to provide active transport systems powered by adenosine triphosphate or adenosine diphosphate that pump fluid out on demand, all skin substitutes, however effective, would be a compromise. Therefore, the best that any current wound covering design can do is to strive to produce all the other qualities of an ideal skin substitute. Recently developed technology utilized in AW BAT attempts to better maximize those attributes.

METHODS:

Desirable traits of an ideal skin substitute include adherence, moisture permeability control, infection control, safety, pain management, physical adaptability, transparency, stability, cost-effectiveness, and ease of application and removal. Analysis of the optimization of these traits exemplifies the proficiency of a skin substitute.

RESULTS:

Improvements in porosity and manufacturing methodology intend to increase AWBAT's capability over existing products to better fulfill the ideal properties of a skin substitute.

CONCLUSION:

It is expected that new technological improvements in AWBAT will provide improved performance over existing skin substitutes. Increased porosity and continuity of the 3-dimensional silicone-nylon membrane are expected to improve acute adherence and reduce the potential for infection associated with fluid accumulation, and the elimination of cross-linking agents in the collagen application is expected to improve the interaction with fibrin and eliminate the potential for allergic reaction to those agents.

• Authors: E Aubrey Woodroof
• Journal: Eplasty (Eplasty) Vol. 9 Pg. e10 ( 2009) ISSN: 1937-5719 [Electronic] United States
• PMID: 19279675 (Publication Type: Journal Article)