Interferon-alpha for treatment of essential thrombocythemia during pregnancy: case report and review of the literature.

Abstract

Described as a myeloproliferative disorder mainly affecting elderly women, recent reports now confirm the occurrence of essential thrombocythemia at younger ages, which questions treatment during pregnancy. We report a further case of uneventful full term pregnancy with the use of interferon-alpha for maternal essential thrombocythemia which suggests that interferon-alpha could be considered as an effective and safe treatment during pregnancy for women with essential thrombocythemia. Further studies are warranted to determine whether interferon-alpha is the optimal therapeutic option during pregnancy for this patient population.

• Authors: Jérémy Séror, Loïc Sentilhes, Céline Lefebvre-Lacoeuille, Loïc Marpeau
• Journal: Fetal diagnosis and therapy (Fetal Diagn Ther) Vol. 25 Issue 1 Pg. 136-40 ( 2009) ISSN: 1421-9964 [Electronic] Switzerland
• PMID: 19279390 (Publication Type: Case Reports, Journal Article, Review)
• Copyright: (c) 2009 S. Karger AG, Basel.

Chemical References

• Interferon-alpha

Topics

• Adult
• Female
• Humans
• Infant
• Infant, Newborn
• Interferon-alpha (adverse effects, therapeutic use)
• Maternal Exposure
• Pregnancy
• Risk Assessment
• Thrombocythemia, Essential (drug therapy)