Abstract | BACKGROUND: DESIGN AND METHODS: RESULTS: The cumulative incidence of non-relapse mortality and relapse at 3 years was 37% and 31%, respectively. In a multivariate analysis significant factors for relapse were not being in complete remission at the time of transplantation (p=0.002), abnormal cytogenetics (p=0.005), higher patients' age (p=0.03) and therapy-related myelodysplastic syndrome (p=0.04), while higher non-relapse mortality was influenced by higher patients' age. Furthermore, there was a marked reduction in non-relapse mortality per calendar year during the study period (p<0.001). The 3-year relapse-free and overall survival rates were 33% and 35%, respectively. In a multivariate analysis significant higher overall survival rates were seen per calendar year (p<0.001), for younger age (<40 years) and normal cytogenetics (p=0.05). Using age (<40 years), abnormal cytogenetics and not being in complete remission at the time of transplantation as risk factors, three different risk groups with overall survival rates of 62%, 33% and 24% could be easily distinguished. CONCLUSIONS:
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Authors | Nicolaus Kröger, Ronald Brand, Anja van Biezen, Axel Zander, Judith Dierlamm, Dietger Niederwieser, Agnès Devergie, Tapani Ruutu, Jackie Cornish, Per Ljungman, Alois Gratwohl, Catherine Cordonnier, Dietrich Beelen, Eric Deconinck, Argiris Symeonidis, Theo de Witte, Myelodysplastic Syndromes Subcommittee of The Chronic Leukaemia Working Party of European Group for Blood and Marrow Transplantation (EBMT) |
Journal | Haematologica
(Haematologica)
Vol. 94
Issue 4
Pg. 542-9
(Apr 2009)
ISSN: 1592-8721 [Electronic] Italy |
PMID | 19278968
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Aged
- Child
- Child, Preschool
- Hematopoietic Stem Cell Transplantation
(mortality)
- Humans
- Leukemia, Myeloid, Acute
(chemically induced, mortality, therapy)
- Middle Aged
- Myelodysplastic Syndromes
(chemically induced, mortality, therapy)
- Neoplasms, Second Primary
(epidemiology, mortality, therapy)
- Prognosis
- Retrospective Studies
- Risk Factors
- Transplantation, Homologous
- Treatment Outcome
- Young Adult
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