Polymorphisms of cytochrome P450 1A2 and N-acetyltransferase genes, meat consumption, and risk of colorectal cancer.

Abstract

PURPOSE:

Polymorphic cytochrome P-450 1A2, N-acetyltransferase 1, and 2 are important enzymes involved in the biotransformation of aromatic and heterocyclic amines known as carcinogens for colorectal cancer. A hospital-based study was designed to investigate the association between colorectal cancer and cytochrome P-450 1A2, N-acetyltransferase 1, and N-acetyltransferase 2, with the interaction of meat consumption.

METHODS:

We genotyped these polymorphisms for 727 colorectal cancer cases and 736 healthy controls. Information on sociodemographic characteristics and diet were ascertained using a structured questionnaire.

RESULTS:

The colorectal cancer risk was significantly increased in rapid N-acetyltransferase 1 carriers with high white meat consumption (almost every day) compared to those carrying the slow N-acetyltransferase 1 genotype with low white meat consumption (less than once a week, odds ratio, 3.00; 95 percent confidence interval, 1.83-4.92). Furthermore, a gene-gene interaction between cytochrome P-450 1A2*1C and N-acetyltransferase 1 was found and modulated by white meat consumption.

CONCLUSIONS:

N-acetyltransferase 1 might compete with cytochrome P-450 1A2*1C to increase the colorectal cancer risk in intermediate white meat consumers, whereas the rapid N-acetyltransferase 1 genotype may exert a harmful effect on individuals with high carcinogen exposure.

• Authors: Chih-Ching Yeh, Fung-Chang Sung, Reiping Tang, Chung Rong Chang-Chieh, Ling-Ling Hsieh
• Journal: Diseases of the colon and rectum (Dis Colon Rectum) Vol. 52 Issue 1 Pg. 104-11 (Jan 2009) ISSN: 1530-0358 [Electronic] United States
• PMID: 19273964 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Heterocyclic Compounds
• Isoenzymes
• Cytochrome P-450 CYP1A2
• Arylamine N-Acetyltransferase
• N-acetyltransferase 1
• NAT2 protein, human

Topics

• Acetylation
• Arylamine N-Acetyltransferase (genetics)
• Cocarcinogenesis
• Colorectal Neoplasms (etiology, genetics)
• Cytochrome P-450 CYP1A2 (genetics)
• Diet (adverse effects)
• Genetic Predisposition to Disease
• Genotype
• Heterocyclic Compounds
• Humans
• Isoenzymes (genetics)
• Meat (adverse effects)
• Polymorphism, Genetic
• Risk Factors