Abstract |
One hundred and twenty-eight children aged three to ten years, were studied to determine the effect of premedication on amnesia for the preanesthetic period. Four comparable groups were used: A control group, no premedication; oral trimeprazine tartrate 2 mg/kg, methadone 0.1 mg/kg plus droperidol 0.15 mg/kg (T.M.D.); oral midazolam 0.45 mg/kg; intramuscular midazolam 0.15 mg/kg. Amnesia was tested for four pictorial facts, and for induction of anesthesia. For pictorial facts, both routes of midazolam administration gave a sixty percent incidence of amnesia compared with sixteen percent in the control group (p less than 0.001). The T.M.D. premedication provided a forty-three percent incidence, also better than the control group (p less than 0.05). Induction was remembered by fifty percent of the midazolam children compared with sixty-six percent of the T.M.D. group (p greater than 0.05) and eight-one percent of the control group (p less than 0.05). The potential advantages of amnesia in pediatric premedication are discussed.
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Authors | K A Payne, A R Coetzee, F J Mattheyse |
Journal | Acta anaesthesiologica Belgica
(Acta Anaesthesiol Belg)
Vol. 42
Issue 2
Pg. 101-5
( 1991)
ISSN: 0001-5164 [Print] Belgium |
PMID | 1927235
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Trimeprazine
- Droperidol
- Midazolam
- Methadone
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Topics |
- Administration, Oral
- Amnesia
(chemically induced)
- Child
- Child, Preschool
- Droperidol
(administration & dosage)
- Humans
- Injections, Intramuscular
- Methadone
(administration & dosage)
- Midazolam
(administration & dosage, pharmacology)
- Preanesthetic Medication
- Trimeprazine
(administration & dosage)
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