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Studies on quinones. Part 45: novel 7-aminoisoquinoline-5,8-quinone derivatives with antitumor properties on cancer cell lines.

Abstract
A variety of 7-aminoisoquinoline-5,8-quinone derivatives were prepared from 2,5-dihydroxyacetophenone, methyl aminocrotonate, and the corresponding amines, through a highly efficient three-step sequence. The members of this series were tested on normal human fibroblasts and on a panel of three human cancer cell lines and their redox properties were determined by cyclic voltammetry in acetonitrile. Both the cytotoxicity and antitumor activity of 7-phenylaminoisoquinoline-5,8-quinone derivatives showed correlation with their half wave potentials and lipophilicities.
AuthorsJaime A Valderrama, J Andrea Ibacache, Verónica Arancibia, Jaime Rodriguez, Cristina Theoduloz
JournalBioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 17 Issue 7 Pg. 2894-901 (Apr 01 2009) ISSN: 1464-3391 [Electronic] England
PMID19269832 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Quinones
Topics
  • Antineoplastic Agents (chemical synthesis, chemistry, toxicity)
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Fibroblasts (drug effects)
  • Humans
  • Quinones (chemical synthesis, chemistry, toxicity)

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