Abstract |
A variety of 7-aminoisoquinoline-5,8-quinone derivatives were prepared from 2,5-dihydroxyacetophenone, methyl aminocrotonate, and the corresponding amines, through a highly efficient three-step sequence. The members of this series were tested on normal human fibroblasts and on a panel of three human cancer cell lines and their redox properties were determined by cyclic voltammetry in acetonitrile. Both the cytotoxicity and antitumor activity of 7-phenylaminoisoquinoline-5,8-quinone derivatives showed correlation with their half wave potentials and lipophilicities.
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Authors | Jaime A Valderrama, J Andrea Ibacache, Verónica Arancibia, Jaime Rodriguez, Cristina Theoduloz |
Journal | Bioorganic & medicinal chemistry
(Bioorg Med Chem)
Vol. 17
Issue 7
Pg. 2894-901
(Apr 01 2009)
ISSN: 1464-3391 [Electronic] England |
PMID | 19269832
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Quinones
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Topics |
- Antineoplastic Agents
(chemical synthesis, chemistry, toxicity)
- Cell Line, Tumor
- Drug Screening Assays, Antitumor
- Fibroblasts
(drug effects)
- Humans
- Quinones
(chemical synthesis, chemistry, toxicity)
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