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[Diffuse large B-cell lymphoma presenting with hypoglossal nerve palsy and great occipital neuralgia].

Abstract
A 74-year-old man was hospitalized with hypoglossal nerve paralysis and severe great occipital neuralgia. Enhanced MRI of the head showed tumor on the left petrous bone, which compressed the medulla oblongata. Soluble IL-2 receptor was elevated and malignant lymphoma was clinically diagnosed. PET-CT demonstrated a single hot spot on the spleen. After radiation therapy to the lesion on the petrous bone, splenectomy was performed. Pathological findings established a diagnosis of diffuse large B-cell lymphoma. After chemotherapy consisting of rituximab and THP-COP, complete remission was achieved.
AuthorsYoshitaka Kanai, Mitsuhiro Matsuda, Takayuki Iwanaga, Shigeo Hashimoto, Yasuhiro Maeda, Akihisa Kanamaru, Nobuo Itagaki
Journal[Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 50 Issue 2 Pg. 113-5 (Feb 2009) ISSN: 0485-1439 [Print] Japan
PMID19265306 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Biomarkers, Tumor
  • Receptors, Interleukin-2
Topics
  • Aged
  • Biomarkers, Tumor (blood)
  • Combined Modality Therapy
  • Humans
  • Hypoglossal Nerve Diseases (etiology)
  • Lymphoma, Large B-Cell, Diffuse (complications, diagnosis, therapy)
  • Male
  • Neoplasms, Multiple Primary
  • Neuralgia (etiology)
  • Occipital Bone (innervation)
  • Petrous Bone
  • Receptors, Interleukin-2 (blood)
  • Remission Induction
  • Skull Neoplasms (complications, diagnosis, therapy)
  • Splenic Neoplasms (complications, diagnosis, therapy)

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