Uncontrollable distant effects of botulinum neurotoxin injections.

Abstract

Some dentists propose administering botulinum neurotoxin injections to treat orofacial pain. The scientific literature has documented there are dangerous uncontrollable effects of long-distance traveling of botulinum neurotoxin from the injection site. These distant effects are not technique-specific, not predictable, and cannot be controlled by the amount of neurotoxin, nor by the site administered. These uncontrollable distant effects of "off-label" botulinum neurotoxin injections, at the very least, must be thoroughly disclosed to patients.

• Authors: Joseph Schames, Y Dov Prero, David Schames, Mayer Schames, William Gabriel, Robert Reed
• Journal: Journal of the California Dental Association (J Calif Dent Assoc) Vol. 37 Issue 1 Pg. 44-5 (Jan 2009) ISSN: 1043-2256 [Print] United States
• PMID: 19263628 (Publication Type: Journal Article)

Chemical References

• Cholinergic Antagonists
• Neuromuscular Agents
• Synaptosomal-Associated Protein 25
• Botulinum Toxins, Type A

Topics

• Botulinum Toxins, Type A (adverse effects, pharmacology)
• Cholinergic Antagonists (pharmacology)
• Deglutition Disorders (chemically induced)
• Facial Pain (drug therapy)
• Humans
• Neuromuscular Agents (adverse effects, pharmacology)
• Peripheral Nervous System Diseases (chemically induced)
• Synaptosomal-Associated Protein 25 (antagonists & inhibitors)