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[Impact of human isophane insulin on the evaluation of beta cell functions].

AbstractOBJECTIVE:
To evaluate the beta cell functions with and without human Isophane insulin treatments.
METHODS:
Thirty patients with type 2 diabetes mellitus who followed the human Isophane insulin therapeutic regimen at bedtime were given 100 g steamed bread tests in two consecutive days. Then the human Isophane insulin treatments were stopped and the 100 g steamed bread tests were repeated in the next day. The fasting and 1, 2, 3 h after meal plasma glucose, serum insulin, C-peptide and proinsulin were measured.
RESULTS:
(1) The fasting and 1,2,3 h after meal plasma glucose increased while the serum insulin decreased after the human Isophane insulin treatments were stopped (P<0.05). (2) The fasting and 1, 2 h after meal C peptide increased (P<0.05) after the human Isophane insulin treatments were stopped. (3) The fasting and 1, 2, 3 h after meal proinsulin increased after the human isophane insulin treatments were stopped (P<0.05). (4) The area under the insulin curve decreased, while, the area under the C peptide increased after the human Isophane insulin treatments were stopped (P<0.05).
CONCLUSION:
Human Isophane insulin treatments should not be stopped to evaluate the beta cell functions of the patients who are undergoing Isophane insulin treatment.
AuthorsMei Zhang, Lin Zhang, Ming-jie Huang, Zhong-yun Xiong, Dan Guo, Zhen-mei An
JournalSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (Sichuan Da Xue Xue Bao Yi Xue Ban) Vol. 39 Issue 6 Pg. 989-91 (Nov 2008) ISSN: 1672-173X [Print] China
PMID19253843 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Blood Glucose
  • C-Peptide
  • Insulin
  • Insulin, Isophane
Topics
  • Adult
  • Aged
  • Area Under Curve
  • Blood Glucose (metabolism)
  • C-Peptide (blood)
  • Diabetes Mellitus, Type 2 (drug therapy, physiopathology)
  • Female
  • Glucose Tolerance Test (methods)
  • Humans
  • Insulin (blood)
  • Insulin, Isophane (administration & dosage)
  • Insulin-Secreting Cells (physiology)
  • Male
  • Middle Aged

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