Abstract | PURPOSE: METHODS AND MATERIALS: RESULTS: The follow-up periods for the patients treated without additional chemotherapy were for the 20 Gy and 16 Gy group mean/median/min-max: 9.0/10.0/1.0-20.3 years and 4.0/3.1/0.4-14.1 years, respectively. During the follow-up period, men treated with 16 Gy RT had stable testosterone levels (-1.1%/year, p = 0.4), whereas men treated with 20 Gy had an annual decrease of 2.4% (p = 0.008). For the latter group, the testosterone decrease was most pronounced in the first 5 years, leveling off during the following 5 years. Additionally, more men treated with 20 Gy needed androgen substitution treatment. Our study showed an increased luteinizing hormone level for the men treated with 16 Gy, although this was not significant (p = 0.5). We anticipated a similar increase in the patients treated with 20 Gy but instead observed a decrease (-3.1%, p = 0.01). CONCLUSION: RT at 16 and 20 Gy seem to affect Leydig cell function differently, with 16 Gy RT better preserving testosterone levels and thus being preferred from an endocrinological point of view.
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Authors | Anne K Bang, Jørgen H Petersen, Peter M Petersen, Anna-Maria Andersson, Gedske Daugaard, Niels Jørgensen |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 75
Issue 3
Pg. 672-6
(Nov 01 2009)
ISSN: 1879-355X [Electronic] United States |
PMID | 19250763
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Testosterone
- Luteinizing Hormone
- Follicle Stimulating Hormone
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Topics |
- Adult
- Carcinoma in Situ
(metabolism, radiotherapy)
- Dose-Response Relationship, Radiation
- Follicle Stimulating Hormone
(blood)
- Humans
- Leydig Cells
(metabolism, radiation effects)
- Luteinizing Hormone
(blood)
- Male
- Orchiectomy
- Prospective Studies
- Testicular Neoplasms
(drug therapy, metabolism, radiotherapy, surgery)
- Testosterone
(biosynthesis, blood)
- Time Factors
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