The expression of six biomarkers in the four most common ovarian cancers: correlation with clinicopathological parameters.

Abstract

This study aimed to evaluate the relationship of fascin-1, matrix metalloproteinase (MMP)-2, MMP-9, cortactin, survivin, and epidermal growth factor receptor (EGFR) expression with clinicopathological parameters for the four most common ovarian surface epithelial carcinomas. Six biomarkers were investigated immunohistochemically using tissue microarrays of 185 specimens including 79 serous cystadenocarcinomas, 47 mucinous cystadenocarcinomas, 45 endometrioid adenocarcinomas, and 14 clear cell carcinomas. The four most common ovarian carcinomas showed significant expression of fascin-1, cortactin, survivin, and EGFR, but not of MMP-2 and MMP-9. In addition, higher immunostaining scores for fascin-1 in mucinous cystadenocarcinomas correlated with T stage, N stage, American Joint Committee on Cancer AJCC clinical stage, and a poorer survival rate; for cortactin in serous cystadenocarcinomas correlated with T stage; for cortactin in clear cell carcinomas correlated with T and clinical AJCC stages; and for survivin in clear cell carcinomas correlated with T stage and AJCC clinical stage. In addition, higher immunostaining scores for fascin-1, cortactin, and survivin correlated with poorer tumor differentiation in serous, mucinous, and endometrioid adenocarcinomas. Thus, the expression of fascin-1, cortactin, and survivin may be helpful in evaluating the aggressiveness of ovarian mucinous, serous, and clear cell adenocarcinoma. Additionally, the expression of fascin-1 may be an independent prognostic risk factor in mucinous cystadenocarcinoma.

• Authors: Chih-Kung Lin, Tai-Kuang Chao, Cheng-Ping Yu, Mu-Hsien Yu, Jong-Shiaw Jin
• Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica (APMIS) Vol. 117 Issue 3 Pg. 162-75 (Mar 2009) ISSN: 1600-0463 [Electronic] Denmark
• PMID: 19245589 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• BIRC5 protein, human
• Biomarkers, Tumor
• Carrier Proteins
• Cortactin
• FSCN1 protein, human
• Inhibitor of Apoptosis Proteins
• Microfilament Proteins
• Microtubule-Associated Proteins
• Survivin
• EGFR protein, human
• ErbB Receptors
• Matrix Metalloproteinase 2
• Matrix Metalloproteinase 9

Topics

• Adenocarcinoma, Clear Cell (metabolism, pathology)
• Biomarkers, Tumor (metabolism)
• Carcinoma, Endometrioid (metabolism, pathology)
• Carrier Proteins (metabolism)
• Cortactin (metabolism)
• Cystadenocarcinoma, Mucinous (metabolism, pathology)
• Cystadenocarcinoma, Serous (metabolism, pathology)
• ErbB Receptors (metabolism)
• Female
• Humans
• Immunohistochemistry
• Inhibitor of Apoptosis Proteins
• Matrix Metalloproteinase 2 (metabolism)
• Matrix Metalloproteinase 9 (metabolism)
• Microfilament Proteins (metabolism)
• Microtubule-Associated Proteins (metabolism)
• Neoplasm Staging
• Ovarian Neoplasms (metabolism, pathology)
• Prognosis
• Survivin